Calcium Handling Proteins: Structure, Function, and Modulation by Exercise

Overview

Journal Heart Fail Rev

Date 2013 Feb 26

PMID 23436107

Citations 8

Authors

Jamille Locatelli

Leonardo V M de Assis

Mauro C Isoldi

Affiliations

Soon will be listed here.

Abstract

Heart failure is a serious public health issue with a growing prevalence, and it is related with the aging of the population. Hypertension is identified as the main precursor of left ventricular hypertrophy and therefore can lead to diastolic dysfunction and heart failure. Scientific studies have confirmed the beneficial effects of the physical exercise by reducing the blood pressure and improving the functional status of the heart in hypertension. Several proteins are involved in the mobilization of calcium during the coupling excitation-contraction process in the heart among those are sarcoplasmic reticulum Ca(2+)-ATPase, phospholamban, calsequestrin, sodium-calcium exchanger, L-type calcium's channel, and ryanodine receptors. Our goal is to address the beneficial effects of exercise on the calcium handling proteins in a heart with hypertension.

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