Treatment-related Lymphopenia in Patients with Stage III Non-small-cell Lung Cancer

Overview

Journal Cancer Invest

Specialty Oncology

Date 2013 Feb 26

PMID 23432821

Citations 127

Authors

Jian L Campian

Xiaobu Ye

Malcolm Brock

Stuart A Grossman

Affiliations

Soon will be listed here.

Abstract

Background: This study sought to estimate the severity, etiology, and clinical importance of treatment-related lymphopenia in patients with stage III non-small-cell lung cancer.

Methods: Serial lymphocyte counts and survival were analyzed retrospectively in 47 patients accounting for known prognostic factors.

Results: Total lymphocyte counts (TLCs) were normal before therapy and did not change following neoadjuvant chemotherapy. Following radiation, TLC fell by 67% (median 500 cells/mm(3), p <.00001). Multivariate analysis revealed an association between severe TLC and survival (HR 1.70, 95% CI: 0.8-3.6).

Conclusions: Rapid and severe lymphopenia occurred in 50% of patients following radiation which was associated with reduced survival.

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