The Smallest Unit: Effector and Memory CD8(+) T Cell Differentiation on the Single Cell Level

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2013 Feb 21

PMID 23424063

Citations 15

Authors

Veit R Buchholz

Patricia Graf

Dirk H Busch

Affiliations

Soon will be listed here.

Abstract

CD8(+) T cell immune responses provide immediate protection against primary infection and durable memory capable of rapidly fighting off re-infection. Immediate protection and lasting memory are implemented by phenotypically and functionally distinct T cell subsets. While it is now widely accepted that these diverge from a common source of naïve T cells (T(n)), the developmental relation and succession of effector and memory T cell subsets is still under intense debate. Recently, a distinct memory T cell subset has been suggested to possess stem cell-like features, sparking the hope to harness its capacity for self-renewal and diversification for successful therapy of chronic infections or malignant diseases. In this review we highlight current developmental models of memory generation, T cell subset diversification and T cell stemness. We discuss the importance of single cell monitoring techniques for adequately mapping these developmental processes and take a brief look at signaling components active in the putative stem cell-like memory T cell compartment.

Citing Articles

Survival and division fate programs are preserved but retuned during the naïve to memory CD8 T-cell transition.

Heinzel S, Cheon H, Belz G, Hodgkin P Immunol Cell Biol. 2023; 102(1):46-57.

PMID: 37840018 PMC: 10952575. DOI: 10.1111/imcb.12699.

Modes of Communication between T Cells and Relevance for Immune Responses.

Uhl L, Gerard A Int J Mol Sci. 2020; 21(8).

PMID: 32290500 PMC: 7215318. DOI: 10.3390/ijms21082674.

Lymphatic endothelial cells prime naïve CD8 T cells into memory cells under steady-state conditions.

Vokali E, Yu S, Hirosue S, Rincon-Restrepo M, Duraes F, Scherer S Nat Commun. 2020; 11(1):538.

PMID: 31988323 PMC: 6985113. DOI: 10.1038/s41467-019-14127-9.

Transcriptional and Epigenetic Regulation of Effector and Memory CD8 T Cell Differentiation.

Chen Y, Zander R, Khatun A, Schauder D, Cui W Front Immunol. 2018; 9:2826.

PMID: 30581433 PMC: 6292868. DOI: 10.3389/fimmu.2018.02826.

Paracrine costimulation of IFN-γ signaling by integrins modulates CD8 T cell differentiation.

Krummel M, Mahale J, Uhl L, Hardison E, Mujal A, Mazet J Proc Natl Acad Sci U S A. 2018; 115(45):11585-11590.

PMID: 30348790 PMC: 6233119. DOI: 10.1073/pnas.1804556115.

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