Effects of Manganese Deficiency on Serum Hormones and Biochemical Markers of Bone Metabolism in Chicks

Overview

Journal J Bone Miner Metab

Specialty Endocrinology

Date 2013 Feb 15

PMID 23408160

Citations 10

Authors

Wang Zhaojun

Wang Lin

Wang Zhenyong

Wang Jian

Liu Ran

Affiliations

Soon will be listed here.

Abstract

In order to investigate the effect of manganese (Mn) deficiency on bone metabolism in chicks, ninety 1-day-old male Arbor Acre chicks were randomly divided into 3 groups and each group were given a diet having a different concentration of Mn (60 mg kg(-1), control group; 40 mg kg(-1), Mn-deficient group I; 8.7 mg kg(-1), Mn-deficient group II). The serum was collected at 42 days old. Tests were performed to evaluate the changes in the levels of PTH, CT, ALP, TrACP, HOP TNF-alpha, OC, Mn and Ca in the serum of the chicks and the results showed that the levels of CT, ALP, TrACP, HOP, and Mn decreased markedly (P < 0.05), while PTH, Ca, and TNF-alpha increased markedly (P < 0.05) due to manganese deficiency in the diet, which indicates that Mn deficiency results in disorder of bone regulatory hormones and enzymes of bone metabolism in the serum.

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