Gastrin-induced Proliferation Involves MEK Partner 1 (MP1)

Overview

Journal In Vitro Cell Dev Biol Anim

Publisher Springer

Specialties Biology
Cell Biology

Date 2013 Feb 15

PMID 23408059

Citations 10

Authors

Tonje S Steigedal

Wenche S Prestvik

Linn-Karina M Selvik

Christina S Fjeldbo

Torunn Bruland

Astrid Laegreid

Liv Thommesen

Affiliations

Soon will be listed here.

Abstract

The peptide hormone gastrin is an important factor for the maintenance and homeostasis of the gastric mucosa. We show that gastrin stimulates proliferation in a dose-dependent manner in the human gastric adenocarcinoma cell line AGS-GR. Furthermore, we demonstrate that the MAPK scaffold protein MEK partner 1 (MP1) is important for gastrin-induced phosphorylation of ERK1 and ERK2 and that MP1 promotes gastrin-induced proliferation of AGS-GR cells. Our results suggest a role of MP1 in gastrin-induced cellular responses involved in proliferation and homeostasis of the gastric mucosa.

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