A Rare Case of Primary Infiltrating Neuroendocrine Carcinoma of the Breast

Overview

Journal Iran J Radiol

Publisher Brieflands

Specialty Radiology

Date 2013 Feb 15

PMID 23408015

Citations 11

Authors

Ouzreiah Nawawi

Keat Ying Goh

Kartini Rahmat

Affiliations

Soon will be listed here.

Abstract

Primary neuroendocrine carcinoma of the breast is a very rare malignant tumor. There are not many cases reported in the English literature since it was first documented in 1983. Reports on the imaging features, in particular the ultrasonographic features of this rare tumor are scarce. Herein, we report a case of aggressive primary infiltrating neuroendocrine carcinoma of the breast, masquerading as an inflammatory breast condition in a 22-year-old young lady, perhaps the youngest case ever reported in the English literature. We discuss the imaging features and highlight the Doppler ultrasonographic findings of this rare breast carcinoma. This is the first documentation on Doppler ultrasonographic findings of primary neuroendocrine carcinoma of the breast in the literature.

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References

Samli B, Celik S, Evrensel T, Orhan B, Tasdelen I . Primary neuroendocrine small cell carcinoma of the breast. Arch Pathol Lab Med. 2000; 124(2):296-8. DOI: 10.5858/2000-124-0296-PNSCCT. View

Sebenik M, Nair S, Hamati H . Primary small cell anaplastic carcinoma of the breast diagnosed by fine needle aspiration cytology: a case report. Acta Cytol. 1998; 42(5):1199-203. DOI: 10.1159/000332114. View

Mariscal A, Balliu E, Diaz R, Casas J, Gallart A . Primary oat cell carcinoma of the breast: imaging features. AJR Am J Roentgenol. 2004; 183(4):1169-71. DOI: 10.2214/ajr.183.4.1831169. View

Kwak J, Kim E, Kim M, Choi S, Son E, Oh K . Power Doppler sonography: evaluation of solid breast lesions and correlation with lymph node metastasis. Clin Imaging. 2008; 32(3):167-71. DOI: 10.1016/j.clinimag.2007.12.004. View

Francois A, Chatikhine V, Chevallier B, Ren G, Berry M, Chevrier A . Neuroendocrine primary small cell carcinoma of the breast. Report of a case and review of the literature. Am J Clin Oncol. 1995; 18(2):133-8. DOI: 10.1097/00000421-199504000-00008. View

Rubini G, DEredita G . Tc-99m sestamibi and In-111 DTPA octreotide uptake in breast carcinoma with neurendocrine differentiation. Clin Nucl Med. 2000; 25(6):482-3. DOI: 10.1097/00003072-200006000-00023. View

Gunhan-Bilgen I, Zekioglu O, Ustun E, Memis A, Erhan Y . Neuroendocrine differentiated breast carcinoma: imaging features correlated with clinical and histopathological findings. Eur Radiol. 2003; 13(4):788-93. DOI: 10.1007/s00330-002-1567-z. View

Kitakata H, Yasumoto K, Sudo Y, Minato H, Takahashi Y . A case of primary small cell carcinoma of the breast. Breast Cancer. 2007; 14(4):414-9. DOI: 10.2325/jbcs.14.414. View

Mehta T, Raza S, Baum J . Use of Doppler ultrasound in the evaluation of breast carcinoma. Semin Ultrasound CT MR. 2000; 21(4):297-307. DOI: 10.1016/s0887-2171(00)90024-6. View

10.

Jundt G, Schulz A, Heitz P, Osborn M . Small cell neuroendocrine (oat cell) carcinoma of the male breast. Immunocytochemical and ultrastructural investigations. Virchows Arch A Pathol Anat Histopathol. 1984; 404(2):213-21. DOI: 10.1007/BF00704065. View

11.

Adegbola T, Connolly C, Mortimer G . Small cell neuroendocrine carcinoma of the breast: a report of three cases and review of the literature. J Clin Pathol. 2005; 58(7):775-8. PMC: 1770704. DOI: 10.1136/jcp.2004.020792. View

12.

Wade Jr P, Mills S, Read M, Cloud W, Lambert 3rd M, Smith R . Small cell neuroendocrine (oat cell) carcinoma of the breast. Cancer. 1983; 52(1):121-5. DOI: 10.1002/1097-0142(19830701)52:1<121::aid-cncr2820520122>3.0.co;2-f. View

13.

Kinoshita S, Hirano A, Komine K, Kobayashi S, Kyoda S, Takeyama H . Primary small-cell neuroendocrine carcinoma of the breast: report of a case. Surg Today. 2008; 38(8):734-8. DOI: 10.1007/s00595-007-3716-0. View

14.

Mizukami Y, Takayama T, Takemura A, Ichikawa K, Onoguchi M, Miyati T . Pleomorphic adenoma of the breast. Radiat Med. 2008; 26(7):442-5. DOI: 10.1007/s11604-008-0250-y. View