The Role of Nitrate, Nitrite and N-nitrosamines in Carcinogenesis of Colon Tumours Following Ureterosigmoidostomy

Overview

Journal Urol Res

Specialty Urology

Date 1990 Jan 1

PMID 2339481

Citations 6

Authors

T Kalble

A R Tricker

K Mohring

M R Berger

H Geiss

G Staehler

Affiliations

Soon will be listed here.

Abstract

Urinary diversion in both a rat model for ureterosigmoidostomy and in ureterosigmoidostomy patients result in an increased incidence of colon tumours. Bacterial and chemical investigations on feces-urine mixtures from both the rat model and ureterosigmoidostomy patients showed the presence of a complex nitrate-reducing bacterial flora in both rats and humans. This bacterial flora actively reduced urinary nitrate to nitrite in humans and increased the endogenous formation of N-nitroso compounds. No evidence of urinary nitrate reduction and increased nitrosamine formation in the rectosigmoid of rats was found. The results support the N-nitrosamine theory of carcinogenesis of the colon following ureterosigmoidostomy in humans, but not in rats. As the rat model induces colon carcinomas, factors other than the increased endogenous formation of N-nitroso compounds in the rectosigmoid may contribute to the initiation of colon carcinomas following ureterosigmoidostomy.

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