The Effects of ECE on the Benefits of PMRT for Breast Cancer Patients with Positive Axillary Nodes

Overview

Journal J Radiat Res

Publisher Oxford University Press

Specialties Environmental Health
Oncology
Radiology

Date 2013 Feb 9

PMID 23392824

Citations 4

Authors

Wenwen Geng

Bin Zhang

Danhua Li

Xinrui Liang

Xunchen Cao

Affiliations

Soon will be listed here.

Abstract

Background: The purpose of the present study was to retrospectively evaluate the effects of extracapsular extension (ECE) on the benefits of post-mastectomy radiation therapy (PMRT) for groups of patients with varying numbers of positive axillary nodes (1-3, 4-9 and ≥10 positive axillary nodes).

Methods: A total of 1220 axillary node-positive patients who had received mastectomy were involved in this study. Patients were grouped as 'Radio + /ECE + ', 'Radio-/ECE + ', 'Radio + /ECE-' or 'Radio-/ECE-' according to status of ECE and whether receiving PMRT or not, and were evaluated in terms of local region relapse (LRR) rate. The 5-year and 10-year Kaplan-Meier disease-free survival and overall survival (OS) rates were analyzed.

Results: ECE-positive differed from ECE-negative groups with statistical significance for all comparisons in favor of the ECE-negative group: 5-year locoregional failure-free survival (LRFFS) (82.69% vs 91.83%, P < 0.001), 10-year LRFFS (75.39% vs 90.02%, P < 0.001); 5-year OS (52.12% vs 74.46%, P < 0.001), 10-year OS (35.17% vs 67.63%, P < 0.001). There were no significant effects of ECE on the benefits of PMRT for patients with 1-3 (P = 0.5720), ≥10(P = 0.0614) positive axillary nodes. However, for the group of patients with 4-9 positive axillary nodes, ECE status had a significant effect on the benefits of PMRT with respect to 5-year and 10-year LRFFS (P < 0.05).

Conclusion: In our study, regardless of the ECE status, PMRT didn't significantly improve the LRFFS for patients with 1-3 or ≥10 positive axillary nodes. However, for patients with 4-9 positive axillary nodes, ECE could be an important criterion to consider when deciding whether to receive PMRT.

Citing Articles

The Significance of Extent of Extracapsular Extension in Patients with T1-2 and N1 Breast Cancer.

Kanyilmaz G, Findik S, Yavuz B, Aktan M Eur J Breast Health. 2018; 14(4):218-224.

PMID: 30288496 PMC: 6170024. DOI: 10.5152/ejbh.2018.4038.

Role of postmastectomy radiation therapy in breast cancer patients with T1-2 and 1-3 positive lymph nodes.

Benderli Cihan Y, Sarigoz T Onco Targets Ther. 2016; 9:5587-95.

PMID: 27672329 PMC: 5024763. DOI: 10.2147/OTT.S106871.

Effects of postmastectomy radiotherapy on prognosis in different tumor stages of breast cancer patients with positive axillary lymph nodes.

Jia M, Liang Z, Chen Q, Zheng Y, Li L, Cao X Cancer Biol Med. 2014; 11(2):123-9.

PMID: 25009754 PMC: 4069797. DOI: 10.7497/j.issn.2095-3941.2014.02.007.

DEGRO practical guidelines for radiotherapy of breast cancer IV: radiotherapy following mastectomy for invasive breast cancer.

Wenz F, Sperk E, Budach W, Dunst J, Feyer P, Fietkau R Strahlenther Onkol. 2014; 190(8):705-14.

PMID: 24888511 DOI: 10.1007/s00066-014-0687-0.

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