Post-stroke Epilepsy in Young Adults: a Long-term Follow-up Study

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2013 Feb 8

PMID 23390537

Citations 38

Authors

Renate Arntz

Loes Rutten-Jacobs

Noortje Maaijwee

Hennie Schoonderwaldt

Lucille Dorresteijn

Ewoud van Dijk

Frank-Erik de Leeuw

Affiliations

Soon will be listed here.

Abstract

Background: Little is known about the incidence and risk of seizures after stroke in young adults. Especially in the young seizures might dramatically influence prognosis and quality of life. We therefore investigated the long-term incidence and risk of post-stroke epilepsy in young adults with a transient ischemic attack (TIA), ischemic stroke (IS) or intracerebral hemorrhage (ICH).

Methods And Findings: We performed a prospective cohort study among 697 consecutive patients with a first-ever TIA, IS or ICH, aged 18-50 years, admitted to our hospital between 1-1-1980 till 1-11-2010. The occurrence of epilepsy was assessed by standardized questionnaires and verified by a neurologist. Cumulative risks were estimated with Kaplan-Meier analysis. Cox proportional hazard models were used to calculate relative risks. After mean follow-up of 9.1 years (SD 8.2), 79 (11.3%) patients developed post-stroke epilepsy and 39 patients (5.6%) developed epilepsy with recurrent seizures. Patients with an initial late seizure more often developed recurrent seizures than patients with an initial early seizure. Cumulative risk of epilepsy was 31%, 16% and 5% for patients with an ICH, IS and TIA respectively (Logrank test ICH and IS versus TIA p<0.001). Cumulative risk of epilepsy with recurrent seizures was 23%, 8% and 4% respectively (Logrank ICH versus IS p = 0.05, ICH versus TIA p<0.001, IS versus TIA p = 0.01). In addition a high NIHSS was a significant predictor of both epilepsy and epilepsy with recurrent seizures (HR 1.07, 95% CI 1.03-1.11 and 1.08, 95% CI 1.02-1.14).

Conclusions: Post-stroke epilepsy is much more common than previously thought. Especially patients with an ICH and a high NIHSS are at high risk. This calls upon the question whether a subgroup could be identified which benefits from the use of prophylactic antiepileptic medication. Future studies should be executed to investigate risk factors and the effect of post-stroke epilepsy on quality of life.

Citing Articles

Clinical approaches for poststroke seizure: a review.

Ryu H, Kim H, Shin B, Kang H Front Neurol. 2024; 15:1337960.

PMID: 38660095 PMC: 11039895. DOI: 10.3389/fneur.2024.1337960.

Post-stroke seizures, epilepsy, and mortality in a prospective hospital-based study.

Freiman S, Hauser W, Rider F, Yaroslavskaya S, Sazina O, Vladimirova E Front Neurol. 2023; 14:1273270.

PMID: 38107633 PMC: 10722584. DOI: 10.3389/fneur.2023.1273270.

Incidence and risk factors of post-stroke seizures and epilepsy: systematic review and meta-analysis.

Nandan A, Zhou Y, Demoe L, Waheed A, Jain P, Widjaja E J Int Med Res. 2023; 51(11):3000605231213231.

PMID: 38008901 PMC: 10683575. DOI: 10.1177/03000605231213231.

Functional brain connectivity in young adults with post-stroke epilepsy.

Boot E, Omes Q, Maaijwee N, Schaapsmeerders P, Arntz R, Rutten-Jacobs L Brain Commun. 2023; 5(6):fcad277.

PMID: 37953839 PMC: 10639092. DOI: 10.1093/braincomms/fcad277.

Stroke in Young Adults.

Bukhari S, Yaghi S, Bashir Z J Clin Med. 2023; 12(15).

PMID: 37568401 PMC: 10420127. DOI: 10.3390/jcm12154999.

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