Prognostic Significance of PDCD4 Expression in Human Salivary Adenoid Cystic Carcinoma

Overview

Journal Med Oncol

Publisher Springer

Specialty Oncology

Date 2013 Feb 8

PMID 23389919

Citations 6

Authors

Cheng Qi

Yi Shao

Ning Li

Chunyan Zhang

Miaoqing Zhao

Fei Gao

Affiliations

Soon will be listed here.

Abstract

Programmed cell death 4 (PDCD4) has been recognized as a tumor suppressor gene that may inhibit neoplastic transformation and tumor promotion/progression. It was demonstrated that PDCD4 expression was associated with prognosis of multiple types of tumors and cancers. However, PDCD4 expression in salivary adenoid cystic carcinoma (ACC) has not been studied. We analyzed PDCD4 protein level by immunohistochemistry in 96 cases of ACC and found that PDCD4 expression was downregulated in 64.6 % (62/96) of tumor samples compared with adjacent nontumor salivary gland tissues. Moreover, decreased PDCD4 expression was significantly associated with clinical stage of the disease (P < 0.01). Analyses of overall survival and disease-specific survival by Kaplan-Meier method revealed that poor prognosis of ACC patients was associated with decreased PDCD4 expression (χ (2) = 5.971, P = 0.013; χ (2) = 4.274, P = 0.029). Furthermore, multivariate Cox model analysis demonstrated that PDCD4 expression was an independent risk factor for ACC (P < 0.05). Thus, our study suggested, for the first time, that PDCD4 expression might have an essential role in the progression of ACC.

Citing Articles

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Hu J, Wang Z, Wang J, Jian Y, Dai J, Wang X Onco Targets Ther. 2020; 13:9159-9167.

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Transcriptomes define distinct subgroups of salivary gland adenoid cystic carcinoma with different driver mutations and outcomes.

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Downregulation of PDCD4 by miR-21 suppresses tumor transformation and proliferation in a nude mouse renal cancer model.

Yuan H, Xin S, Huang Y, Bao Y, Jiang H, Zhou L Oncol Lett. 2017; 14(3):3371-3378.

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The clinical association of programmed cell death protein 4 (PDCD4) with solid tumors and its prognostic significance: a meta-analysis.

Li J, Gao W, Ho W, Lei W, Wei W, Yu-Wai Chan J Chin J Cancer. 2016; 35(1):95.

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miR-21 regulates tumor progression through the miR-21-PDCD4-Stat3 pathway in human salivary adenoid cystic carcinoma.

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PMID: 26367487 DOI: 10.1038/labinvest.2015.105.

References

Khan A, DiGiovanna M, Ross D, Sasaki C, Carter D, Son Y . Adenoid cystic carcinoma: a retrospective clinical review. Int J Cancer. 2001; 96(3):149-58. DOI: 10.1002/ijc.1013. View

Cmarik J, Min H, Hegamyer G, Zhan S, Kulesz-Martin M, Yoshinaga H . Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation. Proc Natl Acad Sci U S A. 1999; 96(24):14037-42. PMC: 24186. DOI: 10.1073/pnas.96.24.14037. View

Goke R, Barth P, Schmidt A, Samans B, Lankat-Buttgereit B . Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21(Waf1/Cip1). Am J Physiol Cell Physiol. 2004; 287(6):C1541-6. DOI: 10.1152/ajpcell.00025.2004. View

Dorrello N, Peschiaroli A, Guardavaccaro D, Colburn N, Sherman N, Pagano M . S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth. Science. 2006; 314(5798):467-71. DOI: 10.1126/science.1130276. View

Suzuki C, Garces R, Edmonds K, Hiller S, Hyberts S, Marintchev A . PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains. Proc Natl Acad Sci U S A. 2008; 105(9):3274-9. PMC: 2265113. DOI: 10.1073/pnas.0712235105. View

Godge P, Sharma S, Yadav M . Adenoid cystic carcinoma of the parotid gland. Contemp Clin Dent. 2012; 3(2):223-6. PMC: 3425113. DOI: 10.4103/0976-237X.96838. View

Dincer N, Guler Tezel G, Sungur A, Himmetoglu C, Huebner K, Guler G . Study of FHIT and WWOX expression in mucoepidermoid carcinoma and adenoid cystic carcinoma of salivary gland. Oral Oncol. 2010; 46(3):195-9. DOI: 10.1016/j.oraloncology.2009.12.003. View

Liu J, Shao C, Tan M, Mu D, Ferris R, Ha P . Molecular biology of adenoid cystic carcinoma. Head Neck. 2011; 34(11):1665-77. PMC: 3262103. DOI: 10.1002/hed.21849. View

Shibuya H, Iinuma H, Shimada R, Horiuchi A, Watanabe T . Clinicopathological and prognostic value of microRNA-21 and microRNA-155 in colorectal cancer. Oncology. 2011; 79(3-4):313-20. DOI: 10.1159/000323283. View

10.

Ma G, Guo K, Zhang H, Ozaki I, Matsuhashi S, Zheng X . [Expression of programmed cell death 4 and its clinicopathological significance in human pancreatic cancer]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2005; 27(5):597-600. View

11.

Schlichter U, Kattmann D, Appl H, Miethe J, Klempnauer K . Identification of the myb-inducible promoter of the chicken Pdcd4 gene. Biochim Biophys Acta. 2001; 1520(1):99-104. DOI: 10.1016/s0167-4781(01)00252-4. View

12.

Hsu T, Young M, Cmarik J, Colburn N . Activator protein 1 (AP-1)- and nuclear factor kappaB (NF-kappaB)-dependent transcriptional events in carcinogenesis. Free Radic Biol Med. 2000; 28(9):1338-48. DOI: 10.1016/s0891-5849(00)00220-3. View

13.

Andry G, Hamoir M, Locati L, Licitra L, Langendijk J . Management of salivary gland tumors. Expert Rev Anticancer Ther. 2012; 12(9):1161-8. DOI: 10.1586/era.12.92. View

14.

Dhar A, Young M, Colburn N . The role of AP-1, NF-kappaB and ROS/NOS in skin carcinogenesis: the JB6 model is predictive. Mol Cell Biochem. 2002; 234-235(1-2):185-93. View

15.

Ding L, Zhang X, Zhao M, Qu Z, Huang S, Dong M . An essential role of PDCD4 in progression and malignant proliferation of gastrointestinal stromal tumors. Med Oncol. 2011; 29(3):1758-64. DOI: 10.1007/s12032-011-0042-6. View

16.

Gao F, Zhang P, Zhou C, Li J, Wang Q, Zhu F . Frequent loss of PDCD4 expression in human glioma: possible role in the tumorigenesis of glioma. Oncol Rep. 2006; 17(1):123-8. View

17.

Nishimine M, Nakamura M, Kishi M, Okamoto M, Shimada K, Ishida E . Alterations of p14ARF and p16INK4a genes in salivary gland carcinomas. Oncol Rep. 2003; 10(3):555-60. View

18.

Wang Y, Ding L, Zhang X, Zhao M, Qu Z, Huang S . Clinical significance of programmed cell death 4 expression in malignant progression of human nasal inverted papillomas. Med Oncol. 2012; 29(4):2505-11. DOI: 10.1007/s12032-012-0185-0. View

19.

Wei Z, Zhang X, Wang X, Gao F, Zhou C, Zhu F . PDCD4 inhibits the malignant phenotype of ovarian cancer cells. Cancer Sci. 2009; 100(8):1408-13. PMC: 11159598. DOI: 10.1111/j.1349-7006.2009.01210.x. View

20.

Goke A, Goke R, Knolle A, Trusheim H, Schmidt H, Wilmen A . DUG is a novel homologue of translation initiation factor 4G that binds eIF4A. Biochem Biophys Res Commun. 2002; 297(1):78-82. DOI: 10.1016/s0006-291x(02)02129-0. View