Tumor-infiltrating Immune Cells Promoting Tumor Invasion and Metastasis: Existing Theories

Overview

Journal J Cancer

Specialty Oncology

Date 2013 Feb 7

PMID 23386907

Citations 105

Authors

Yan-Gao Man

Alexander Stojadinovic

Jeffrey Mason

Itzhak Avital

Anton Bilchik

Bjoern Bruecher

Mladjan Protic

Aviram Nissan

Mina Izadjoo

Xichen Zhang

Anahid Jewett

Affiliations

Soon will be listed here.

Abstract

It is a commonly held belief that infiltration of immune cells into tumor tissues and direct physical contact between tumor cells and infiltrated immune cells is associated with physical destructions of the tumor cells, reduction of the tumor burden, and improved clinical prognosis. An increasing number of studies, however, have suggested that aberrant infiltration of immune cells into tumor or normal tissues may promote tumor progression, invasion, and metastasis. Neither the primary reason for these contradictory observations, nor the mechanism for the reported diverse impact of tumor-infiltrating immune cells has been elucidated, making it difficult to judge the clinical implications of infiltration of immune cells within tumor tissues. This mini-review presents several existing hypotheses and models that favor the promoting impact of tumor-infiltrating immune cells on tumor invasion and metastasis, and also analyzes their strength and weakness.

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