Physiological Role of β-catenin/TCF Signaling in Neurons of the Adult Brain

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 2013 Feb 5

PMID 23377854

Citations 48

Authors

Marta B Wisniewska

Affiliations

Soon will be listed here.

Abstract

Wnt/β-catenin pathway, the effectors of which are transcription factors of the LEF1/TCF family, is primarily associated with development. Strikingly, however, some of the genes of the pathway are schizophrenia susceptibility genes, and the proteins that are often mutated in neurodegenerative diseases have the ability to regulate β-catenin levels. If impairment of this pathway indeed leads to these pathologies, then it likely plays a physiological role in the adult brain. This review provides an overview of the current knowledge on this subject. The involvement of β-catenin and LEF1/TCF factors in adult neurogenesis, synaptic plasticity, and the function of thalamic neurons are discussed. The data are still very preliminary and often based on circumstantial or indirect evidence. Further research might help to understand the etiology of the aforementioned pathologies.

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References

Backman M, Machon O, Mygland L, van den Bout C, Zhong W, Taketo M . Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon. Dev Biol. 2005; 279(1):155-68. DOI: 10.1016/j.ydbio.2004.12.010. View

Bylund M, Andersson E, Novitch B, Muhr J . Vertebrate neurogenesis is counteracted by Sox1-3 activity. Nat Neurosci. 2003; 6(11):1162-8. DOI: 10.1038/nn1131. View

Decimo I, Bifari F, Krampera M, Fumagalli G . Neural stem cell niches in health and diseases. Curr Pharm Des. 2012; 18(13):1755-83. PMC: 3343380. DOI: 10.2174/138161212799859611. View

Lucas J, Hernandez F, Avila J . Nuclear localization of beta-catenin in adult mouse thalamus correlates with low levels of GSK-3beta. Neuroreport. 1999; 10(13):2699-703. DOI: 10.1097/00001756-199909090-00002. View

Perego C, Vanoni C, Massari S, Longhi R, Pietrini G . Mammalian LIN-7 PDZ proteins associate with beta-catenin at the cell-cell junctions of epithelia and neurons. EMBO J. 2000; 19(15):3978-89. PMC: 306606. DOI: 10.1093/emboj/19.15.3978. View

Yu J, Kim J, Song G, Jung J . Increase in proliferation and differentiation of neural progenitor cells isolated from postnatal and adult mice brain by Wnt-3a and Wnt-5a. Mol Cell Biochem. 2006; 288(1-2):17-28. DOI: 10.1007/s11010-005-9113-3. View

Chenn A, Walsh C . Increased neuronal production, enlarged forebrains and cytoarchitectural distortions in beta-catenin overexpressing transgenic mice. Cereb Cortex. 2003; 13(6):599-606. DOI: 10.1093/cercor/13.6.599. View

Wisniewska M, Misztal K, Michowski W, Szczot M, Purta E, Lesniak W . LEF1/beta-catenin complex regulates transcription of the Cav3.1 calcium channel gene (Cacna1g) in thalamic neurons of the adult brain. J Neurosci. 2010; 30(14):4957-69. PMC: 6632775. DOI: 10.1523/JNEUROSCI.1425-09.2010. View

Ward L . The thalamic dynamic core theory of conscious experience. Conscious Cogn. 2011; 20(2):464-86. DOI: 10.1016/j.concog.2011.01.007. View

10.

Hansen T, Ingason A, Djurovic S, Melle I, Fenger M, Gustafsson O . At-risk variant in TCF7L2 for type II diabetes increases risk of schizophrenia. Biol Psychiatry. 2011; 70(1):59-63. DOI: 10.1016/j.biopsych.2011.01.031. View

11.

Saegusa M, Hashimura M, Kuwata T, Hamano M, Okayasu I . Induction of p16INK4A mediated by beta-catenin in a TCF4-independent manner: implications for alterations in p16INK4A and pRb expression during trans-differentiation of endometrial carcinoma cells. Int J Cancer. 2006; 119(10):2294-303. DOI: 10.1002/ijc.22112. View

12.

Hsieh J . Orchestrating transcriptional control of adult neurogenesis. Genes Dev. 2012; 26(10):1010-21. PMC: 3360557. DOI: 10.1101/gad.187336.112. View

13.

Caroni P, Donato F, Muller D . Structural plasticity upon learning: regulation and functions. Nat Rev Neurosci. 2012; 13(7):478-90. DOI: 10.1038/nrn3258. View

14.

Nishimura W, Yao I, Iida J, Tanaka N, Hata Y . Interaction of synaptic scaffolding molecule and Beta -catenin. J Neurosci. 2002; 22(3):757-65. PMC: 6758496. View

15.

Votin V, Nelson W, Barth A . Neurite outgrowth involves adenomatous polyposis coli protein and beta-catenin. J Cell Sci. 2005; 118(Pt 24):5699-708. PMC: 3373789. DOI: 10.1242/jcs.02679. View

16.

Stambolic V, Ruel L, Woodgett J . Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells. Curr Biol. 1996; 6(12):1664-8. DOI: 10.1016/s0960-9822(02)70790-2. View

17.

Mu Y, Lee S, Gage F . Signaling in adult neurogenesis. Curr Opin Neurobiol. 2010; 20(4):416-23. PMC: 2942965. DOI: 10.1016/j.conb.2010.04.010. View

18.

Ciani L, Salinas P . WNTs in the vertebrate nervous system: from patterning to neuronal connectivity. Nat Rev Neurosci. 2005; 6(5):351-62. DOI: 10.1038/nrn1665. View

19.

Espinosa L, Ingles-Esteve J, Aguilera C, Bigas A . Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathways. J Biol Chem. 2003; 278(34):32227-35. DOI: 10.1074/jbc.M304001200. View

20.

Gao X, Arlotta P, Macklis J, Chen J . Conditional knock-out of beta-catenin in postnatal-born dentate gyrus granule neurons results in dendritic malformation. J Neurosci. 2007; 27(52):14317-25. PMC: 6673436. DOI: 10.1523/JNEUROSCI.3206-07.2007. View