Recruitment of Black Subjects for a Natural History Study of Intracerebral Hemorrhage

Overview

Journal J Health Care Poor Underserved

Publisher Johns Hopkins University Press

Date 2013 Feb 5

PMID 23377714

Citations 2

Authors

Dorothy F Edwards

Ravi Menon

Ali Fokar

Christopher Gibbons

Jeffrey Wing

Brisa Sanchez

Chelsea S Kidwell

Affiliations

Soon will be listed here.

Abstract

Historically, recruitment of minority subjects for clinical research has been challenging. We developed culturally-tailored recruitment materials for a longitudinal, natural history study of intracerebral hemorrhage (ICH) and trained recruiting coordinators in cultural competence. Of 285 subjects meeting inclusion criteria, 158 (55% of those eligible) agreed to participate (60% of eligible Blacks vs. 45% of eligible non-Blacks, p..02). Of those enrolled, 138 (87%) agreed to participate in the genetic sub-study (86% of Blacks vs. 90% of non-Blacks enrolled, p..78). Of those subjects who refused enrollment, lack of interest in research (42%) was the most common reason given for the study as a whole. A higher rate of enrollment was achieved in Blacks vs. non-Blacks in this ICH clinical research study employing culturally tailored recruitment approaches and training of recruitment coordinators to overcome traditional recruitment barriers to research participation in minority patients.

Citing Articles

High tech and high touch: Recruitment strategies for enrolling African American stroke survivors in Community Based Intervention under Nurse Guidance after stroke (CINGS) trial.

Magwood G, Ellis C, Buie J, Slan S, Bonilha L, Adams R Contemp Clin Trials Commun. 2021; 24:100844.

PMID: 34541374 PMC: 8441066. DOI: 10.1016/j.conctc.2021.100844.

Building a "Deep Fund of Good Will": Reframing Research Engagement.

Passmore S, Fryer C, Butler 3rd J, Garza M, Thomas S, Quinn S J Health Care Poor Underserved. 2016; 27(2):722-40.

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References

Brown D, Topcu M . Willingness to participate in clinical treatment research among older African Americans and Whites. Gerontologist. 2003; 43(1):62-72. DOI: 10.1093/geront/43.1.62. View

Heiat A, Gross C, Krumholz H . Representation of the elderly, women, and minorities in heart failure clinical trials. Arch Intern Med. 2002; 162(15):1682-8. DOI: 10.1001/archinte.162.15.1682. View

Phipps E, Harris D, Brown N, Harralson T, Brecher A, Polansky M . Investigation of ethnic differences in willingness to enroll in a rehabilitation research registry: a study of the Northeast Cognitive Rehabilitation Research Network. Am J Phys Med Rehabil. 2004; 83(12):875-83. DOI: 10.1097/01.phm.0000143436.57173.e1. View

Roger V, Go A, Lloyd-Jones D, Benjamin E, Berry J, Borden W . Heart disease and stroke statistics--2012 update: a report from the American Heart Association. Circulation. 2011; 125(1):e2-e220. PMC: 4440543. DOI: 10.1161/CIR.0b013e31823ac046. View

Sugarman J, Sitlani C, Andrusiek D, Aufderheide T, Bulger E, Davis D . Is the enrollment of racial and ethnic minorities in research in the emergency setting equitable?. Resuscitation. 2009; 80(6):644-9. PMC: 2692408. DOI: 10.1016/j.resuscitation.2009.03.015. View

Nicholson L, Schwirian P, Klein E, Skybo T, Murray-Johnson L, Eneli I . Recruitment and retention strategies in longitudinal clinical studies with low-income populations. Contemp Clin Trials. 2011; 32(3):353-62. PMC: 3070062. DOI: 10.1016/j.cct.2011.01.007. View

Moye L . Clinical trial minority recruitment: still an unmet need. J Natl Med Assoc. 2002; 94(4):272-4. PMC: 2594210. View

Johnson V, Powell-Young Y, Torres E, Spruill I . A systematic review of strategies that increase the recruitment and retention of African American adults in genetic and genomic studies. ABNF J. 2011; 22(4):84-8. PMC: 3439996. View

Toerien M, Brookes S, Metcalfe C, de Salis I, Tomlin Z, Peters T . A review of reporting of participant recruitment and retention in RCTs in six major journals. Trials. 2009; 10:52. PMC: 2717957. DOI: 10.1186/1745-6215-10-52. View

10.

Scharff D, Mathews K, Jackson P, Hoffsuemmer J, Martin E, Edwards D . More than Tuskegee: understanding mistrust about research participation. J Health Care Poor Underserved. 2010; 21(3):879-97. PMC: 4354806. DOI: 10.1353/hpu.0.0323. View

11.

Gorelick P, Harris Y, Burnett B, Bonecutter F . The recruitment triangle: reasons why African Americans enroll, refuse to enroll, or voluntarily withdraw from a clinical trial. An interim report from the African-American Antiplatelet Stroke Prevention Study (AAASPS). J Natl Med Assoc. 1998; 90(3):141-5. PMC: 2608331. View

12.

Kasner S, Del Giudice A, Rosenberg S, Sheen M, Luciano J, Cucchiara B . Who will participate in acute stroke trials?. Neurology. 2009; 72(19):1682-8. PMC: 2683644. DOI: 10.1212/WNL.0b013e3181a55fbe. View

13.

Heiney S, Adams S, Wells L, Johnson H . Evaluation of conceptual framework for recruitment of African American patients with breast cancer. Oncol Nurs Forum. 2010; 37(3):E160-7. PMC: 2946071. DOI: 10.1188/10.ONF.E160-E167. View

14.

Cruz-Flores S, Rabinstein A, Biller J, Elkind M, Griffith P, Gorelick P . Racial-ethnic disparities in stroke care: the American experience: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011; 42(7):2091-116. DOI: 10.1161/STR.0b013e3182213e24. View

15.

Ejiogu N, Norbeck J, Mason M, Cromwell B, Zonderman A, Evans M . Recruitment and retention strategies for minority or poor clinical research participants: lessons from the Healthy Aging in Neighborhoods of Diversity across the Life Span study. Gerontologist. 2011; 51 Suppl 1:S33-45. PMC: 3092978. DOI: 10.1093/geront/gnr027. View

16.

Braunstein J, Sherber N, Schulman S, Ding E, Powe N . Race, medical researcher distrust, perceived harm, and willingness to participate in cardiovascular prevention trials. Medicine (Baltimore). 2008; 87(1):1-9. DOI: 10.1097/MD.0b013e3181625d78. View

17.

Joseph G, Dohan D . Recruiting minorities where they receive care: Institutional barriers to cancer clinical trials recruitment in a safety-net hospital. Contemp Clin Trials. 2009; 30(6):552-9. DOI: 10.1016/j.cct.2009.06.009. View

18.

Sivarajan Froelicher E, Doolan D, Yerger V, McGruder C, Malone R . Combining community participatory research with a randomized clinical trial: the Protecting the Hood Against Tobacco (PHAT) smoking cessation study. Heart Lung. 2010; 39(1):50-63. DOI: 10.1016/j.hrtlng.2009.06.004. View

19.

Patterson A, Davis H, Shelby K, McCoy J, Robinson L, Rao S . Successful strategies for increasing African American participation in cancer genetic studies: hopeful signs for equalizing the benefits of genetic medicine. Community Genet. 2008; 11(4):208-14. DOI: 10.1159/000116881. View

20.

Kitterman D, Cheng S, Dilts D, Orwoll E . The prevalence and economic impact of low-enrolling clinical studies at an academic medical center. Acad Med. 2011; 86(11):1360-6. PMC: 3203249. DOI: 10.1097/ACM.0b013e3182306440. View