Skeletal Muscle Aging and the Mitochondrion

Overview

Journal Trends Endocrinol Metab

Specialty Endocrinology

Date 2013 Feb 5

PMID 23375520

Citations 99

Authors

Matthew L Johnson

Matthew M Robinson

K Sreekumaran Nair

Affiliations

Soon will be listed here.

Abstract

Decline in human muscle mass and strength (sarcopenia) is a hallmark of the aging process. A growing body of research in the areas of bioenergetics and protein turnover has placed the mitochondria at the center of this process. It is now clear that, unless an active lifestyle is rigorously followed, skeletal muscle mitochondrial decline occurs as humans age. Increasing research on mitochondrial biology has elucidated the regulatory pathways involved in mitochondrial biogenesis, many of which are potential therapeutic targets, and highlight the beneficial effects of vigorous physical activity on skeletal muscle health for an aging population.

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