Bisphenol A Accelerates Toxic Amyloid Formation of Human Islet Amyloid Polypeptide: a Possible Link Between Bisphenol A Exposure and Type 2 Diabetes

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2013 Feb 2

PMID 23372685

Citations 20

Authors

Hao Gong

Xin Zhang

Biao Cheng

Yue Sun

Chuanzhou Li

Ting Li

Ling Zheng

Kun Huang

Affiliations

Soon will be listed here.

Abstract

Bisphenol A (BPA) is a chemical compound widely used in manufacturing plastic products. Recent epidemiological studies suggest BPA exposure is positively associated with the incidence of type 2 diabetes mellitus (T2DM), however the mechanisms underlying this link remain unclear. Human islet amyloid polypeptide (hIAPP) is a hormone synthesized and secreted by the pancreatic β-cells. Misfolding of hIAPP into toxic oligomers and mature fibrils can disrupt cell membrane and lead to β-cell death, which is regarded as one of the causative factors of T2DM. To test whether there are any connections between BPA exposure and hIAPP misfolding, we investigated the effects of BPA on hIAPP aggregation using thioflavin-T based fluorescence, transmission electronic microscopy, circular dichroism, dynamic light scattering, size-exclusion chromatography, fluorescence-dye leakage assay in an artificial micelle system and the generation of reactive oxygen species in INS-1 cells. We demonstrated that BPA not only dose-dependently promotes the aggregation of hIAPP and enhances the membrane disruption effects of hIAPP, but also promotes the extent of hIAPP aggregation related oxidative stress. Taken together, our results suggest that BPA exposure increased T2DM risk may involve the exacerbated toxic aggregation of hIAPP.

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