Assessment of Placental Oxidative Stress in Pre-eclampsia

Overview

Journal J Obstet Gynaecol India

Specialty Gynecology & Obstetrics

Date 2013 Feb 2

PMID 23372288

Citations 3

Authors

Brahmarshi Das

Santa Saha-Roy

Anindya Das Gupta

Tapan Kumar Lahiri

Harendra Nath Das

Affiliations

Soon will be listed here.

Abstract

Objective: To study oxidative stress in placental tissue as well as in serum in pre-eclamptic women.

Methods: Fifty pre-eclamptic cases and fifty normal pregnant women were selected in the study. Thio barbituric acid reacting substances (TBARS) was measured as oxidative stress marker and superoxide dismutase (SOD) and GSH (reduced glutathione) were measured for assessment of antioxidant status in placental tissue extract and serum.

Results: TBARS and SOD activity were increased significantly (P < 0.001) in both placental homogenate and serum in pre-eclamptic women. Level of GSH was not altered much.

Conclusion: Placental oxidative stress can be assessed by measuring serum oxidative stress markers and this may help in prevention of further progress of this condition.

Citing Articles

The Trace Element Concentrations and Oxidative Stress Parameters in Afterbirths from Women with Multiple Pregnancies.

Grzeszczak K, Kapczuk P, Kupnicka P, Siminska D, Lebdowicz-Knul J, Kwiatkowski S Biomolecules. 2023; 13(5).

PMID: 37238667 PMC: 10216804. DOI: 10.3390/biom13050797.

Plasma Levels of Vitamin A in Early Pregnancy and Correlationship with Hypertensive Disorder.

Lv J, Wang Y, Zhao Y, He Y, Yang H, Zhang H Comput Math Methods Med. 2022; 2022:3081720.

PMID: 35633926 PMC: 9132624. DOI: 10.1155/2022/3081720.

Endothelial dysfunction and preeclampsia: role of oxidative stress.

Sanchez-Aranguren L, Prada C, Riano-Medina C, Lopez M Front Physiol. 2014; 5:372.

PMID: 25346691 PMC: 4193194. DOI: 10.3389/fphys.2014.00372.

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