Sleep Spindle Activity and Cognitive Performance in Healthy Children

Overview

Journal Sleep

Publisher Oxford University Press

Specialty Psychiatry

Date 2013 Feb 2

PMID 23372271

Citations 39

Authors

Alex Chatburn

Scott Coussens

Kurt Lushington

Declan Kennedy

Mathias Baumert

Mark Kohler

Affiliations

Soon will be listed here.

Abstract

Study Objectives: To investigate the association between indices of sleep spindle activity and cognitive performance in a sample of healthy children.

Design: Correlational. Intelligence (Stanford-Binet) and neurocognitive functioning (NEPSY) were assessed, with sleep variables being measured during overnight polysomnography.

Setting: Hospital sleep laboratory.

Participants: Twenty-seven healthy children (mean age 8.19 y; 14 female, 13 male).

Interventions: N/A.

Measurements And Results: Participants underwent a single night of overnight polysomnography after completing measures of intelligence and neurocognitive functioning. Sleep spindles were visually identified by an experienced sleep scoring technician and separated algorithmically into fast (> 13 Hz) and slow spindle (< 13 Hz) categories. The number of fast spindles was significantly correlated with narrative memory (r(s) = 0.38) and sensorimotor functioning (-0.43). Mean central frequency of spindles was also significantly correlated with sensorimotor functioning (-0.41), planning ability (-0.41), and working memory (-0.54).

Conclusions: Basal sleep spindle activity is associated with different aspects of cognitive performance in children. To the extent that these associations in a pediatric population are different from what is known in adult sleep may play an important role in development.

Citing Articles

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References

Mander B, Santhanam S, Saletin J, Walker M . Wake deterioration and sleep restoration of human learning. Curr Biol. 2011; 21(5):R183-4. PMC: 3093247. DOI: 10.1016/j.cub.2011.01.019. View

Bourke R, Anderson V, Yang J, Jackman A, Killedar A, Nixon G . Cognitive and academic functions are impaired in children with all severities of sleep-disordered breathing. Sleep Med. 2011; 12(5):489-96. DOI: 10.1016/j.sleep.2010.11.010. View

Schabus M, Hodlmoser K, Gruber G, Sauter C, Anderer P, Klosch G . Sleep spindle-related activity in the human EEG and its relation to general cognitive and learning abilities. Eur J Neurosci. 2006; 23(7):1738-46. DOI: 10.1111/j.1460-9568.2006.04694.x. View

Diekelmann S, Wilhelm I, Born J . The whats and whens of sleep-dependent memory consolidation. Sleep Med Rev. 2009; 13(5):309-21. DOI: 10.1016/j.smrv.2008.08.002. View

Kopasz M, Loessl B, Hornyak M, Riemann D, Nissen C, Piosczyk H . Sleep and memory in healthy children and adolescents - a critical review. Sleep Med Rev. 2010; 14(3):167-77. DOI: 10.1016/j.smrv.2009.10.006. View

Rapoport J, Castellanos F, Gogate N, Janson K, Kohler S, Nelson P . Imaging normal and abnormal brain development: new perspectives for child psychiatry. Aust N Z J Psychiatry. 2001; 35(3):272-81. DOI: 10.1046/j.1440-1614.2001.00900.x. View

Kuczmarski R, Ogden C, Grummer-Strawn L, Flegal K, Guo S, Wei R . CDC growth charts: United States. Adv Data. 2001; (314):1-27. View

Geiger A, Huber R, Kurth S, Ringli M, Jenni O, Achermann P . The sleep EEG as a marker of intellectual ability in school age children. Sleep. 2011; 34(2):181-9. PMC: 3022938. DOI: 10.1093/sleep/34.2.181. View

Morin A, Doyon J, Dostie V, Barakat M, Hadj Tahar A, Korman M . Motor sequence learning increases sleep spindles and fast frequencies in post-training sleep. Sleep. 2008; 31(8):1149-56. PMC: 2542961. View

10.

Maquet P . Understanding non rapid eye movement sleep through neuroimaging. World J Biol Psychiatry. 2010; 11 Suppl 1:9-15. DOI: 10.3109/15622971003637736. View

11.

. EEG arousals: scoring rules and examples: a preliminary report from the Sleep Disorders Atlas Task Force of the American Sleep Disorders Association. Sleep. 1992; 15(2):173-84. View

12.

Dewald J, Meijer A, Oort F, Kerkhof G, Bogels S . The influence of sleep quality, sleep duration and sleepiness on school performance in children and adolescents: A meta-analytic review. Sleep Med Rev. 2010; 14(3):179-89. DOI: 10.1016/j.smrv.2009.10.004. View

13.

Hori T, Sugita Y, Koga E, Shirakawa S, Inoue K, Uchida S . Proposed supplements and amendments to 'A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects', the Rechtschaffen & Kales (1968) standard. Psychiatry Clin Neurosci. 2001; 55(3):305-10. DOI: 10.1046/j.1440-1819.2001.00810.x. View

14.

Molle M, Bergmann T, Marshall L, Born J . Fast and slow spindles during the sleep slow oscillation: disparate coalescence and engagement in memory processing. Sleep. 2011; 34(10):1411-21. PMC: 3174843. DOI: 10.5665/SLEEP.1290. View

15.

Schabus M, Hoedlmoser K, Pecherstorfer T, Anderer P, Gruber G, Parapatics S . Interindividual sleep spindle differences and their relation to learning-related enhancements. Brain Res. 2008; 1191:127-35. PMC: 2855382. DOI: 10.1016/j.brainres.2007.10.106. View

16.

Barakat M, Doyon J, Debas K, Vandewalle G, Morin A, Poirier G . Fast and slow spindle involvement in the consolidation of a new motor sequence. Behav Brain Res. 2010; 217(1):117-21. DOI: 10.1016/j.bbr.2010.10.019. View

17.

Tucker A . The prospects for enhancing sleep across the lifespan. Sleep. 2011; 34(2):135-6. PMC: 3022931. DOI: 10.1093/sleep/34.2.135. View

18.

Fogel S, Smith C, Beninger R . Too much of a good thing? Elevated baseline sleep spindles predict poor avoidance performance in rats. Brain Res. 2010; 1319:112-7. DOI: 10.1016/j.brainres.2010.01.026. View

19.

Diekelmann S, Born J . The memory function of sleep. Nat Rev Neurosci. 2010; 11(2):114-26. DOI: 10.1038/nrn2762. View

20.

Moser D, Anderer P, Gruber G, Parapatics S, Loretz E, Boeck M . Sleep classification according to AASM and Rechtschaffen & Kales: effects on sleep scoring parameters. Sleep. 2009; 32(2):139-49. PMC: 2635577. DOI: 10.1093/sleep/32.2.139. View