Impact of Protein Supplementation and Care and Support on Body Composition and CD4 Count Among HIV-infected Women Living in Rural India: Results from a Randomized Pilot Clinical Trial

Overview

Journal AIDS Behav

Specialty Infectious Diseases

Date 2013 Feb 2

PMID 23370835

Citations 15

Authors

Adeline Nyamathi

Sanjeev Sinha

Kalyan K Ganguly

Padma Ramakrishna

P Suresh

Catherine L Carpenter

Affiliations

Soon will be listed here.

Abstract

Body composition in HIV-infected individuals is subject to many influences. We conducted a pilot 6-month randomized trial of 68 women living with AIDS (WLA) from rural India. High protein intervention combined with education and supportive care delivered by HIV-trained village women (activated social health activist [Asha] life [AL]) was compared to standard protein with usual care delivered by village community assistants (usual care [UC]). Measurements included CD4 counts, ART adherence, socio-demographics, disease characteristics (questionnaires); and anthropometry (bioimpedance analyzer). Repeated measures analysis of variance modeled associations. AL significantly gained in BMI, muscle mass, fat mass, ART adherence, and CD4 counts compared to UC, with higher weight and muscle mass gains among ART adherent (≥66%) participants who had healthier immunity (CD4 ≥450). BMI of WLA improved through high protein supplementation combined with education and supportive care. Future research is needed to determine which intervention aspect was most responsible.

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