Acetonic and Methanolic Extracts of Heterotheca Inuloides, and Quercetin, Decrease CCl(4)-Oxidative Stress in Several Rat Tissues

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2013 Feb 1

PMID 23365610

Citations 7

Authors

Elvia Coballase-Urrutia

Jose Pedraza-Chaverri

Noemi Cardenas-Rodriguez

Bernardino Huerta-Gertrudis

Mercedes Edna Garcia-Cruz

Hortencia Montesinos-Correa

Dolores Javier Sanchez-Gonzalez

Rafael Camacho-Carranza

Jesus Javier Espinosa-Aguirre

Affiliations

Soon will be listed here.

Abstract

The present study was designed to test the hypothesis that the acetonic and methanolic extracts of H. inuloides prevent carbon tetrachloride-(CCl(4)) induced oxidative stress in vital tissues. Pretreatment with both H. inuloides extracts or quercetin attenuated the increase in serum activity of alkaline phosphatase (ALP), total bilirubin (BB), creatinine (CRE), and creatine kinase (CK), and impeded the decrease of γ-globulin (γ-GLOB) and albumin (ALB) observed in CCl(4)-induced tissue injury. The protective effect was confirmed by histological analysis with hematoxylin-eosin and periodic acid/Schiff's reagent. Level of lipid peroxidation was higher in the organs of rats exposed to CCl(4) than in those of the animals treated with Heterohteca extracts or quercetin, and these showed levels similar to the untreated group. Pretreatment of animals with either of the extracts or quercetin also prevented the increase of 4-hydroxynonenal and 3-nitrotyrosine. Pretreatment with the plant extracts or quercetin attenuated CCl(4) toxic effects on the activity of several antioxidant enzymes. The present results strongly suggest that the chemopreventive effect of the extracts used and quercetin, against CCl(4) toxicity, is associated with their antioxidant properties and corroborated previous results obtained in liver tissue.

Citing Articles

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Dose-Dependent Behavioral and Antioxidant Effects of Quercetin and Methanolic and Acetonic Extracts from on Several Rat Tissues following Kainic Acid-Induced .

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