The Expanding Genetic Toolkit for Exploring Mechanisms of General Anesthesia

Overview

Journal Anesthesiology

Specialty Anesthesiology

Date 2013 Feb 1

PMID 23364596

Authors

Stuart A Forman

Affiliations

Soon will be listed here.

References

Miller G . Optogenetics. Shining new light on neural circuits. Science. 2006; 314(5806):1674-6. DOI: 10.1126/science.314.5806.1674. View

Hill-Venning C, Belelli D, Peters J, Lambert J . Subunit-dependent interaction of the general anaesthetic etomidate with the gamma-aminobutyric acid type A receptor. Br J Pharmacol. 1997; 120(5):749-56. PMC: 1564523. DOI: 10.1038/sj.bjp.0700927. View

Liao M, Sonner J, Husain S, Miller K, Jurd R, Rudolph U . R (+) etomidate and the photoactivable R (+) azietomidate have comparable anesthetic activity in wild-type mice and comparably decreased activity in mice with a N265M point mutation in the gamma-aminobutyric acid receptor beta3 subunit. Anesth Analg. 2005; 101(1):131-5, table of contents. DOI: 10.1213/01.ANE.0000153011.64764.6F. View

Sato Y, Kobayashi E, Murayama T, Mishina M, Seo N . Effect of N-methyl-D-aspartate receptor epsilon1 subunit gene disruption of the action of general anesthetic drugs in mice. Anesthesiology. 2005; 102(3):557-61. DOI: 10.1097/00000542-200503000-00013. View

Desai R, Ruesch D, Forman S . Gamma-amino butyric acid type A receptor mutations at beta2N265 alter etomidate efficacy while preserving basal and agonist-dependent activity. Anesthesiology. 2009; 111(4):774-84. PMC: 2798018. DOI: 10.1097/ALN.0b013e3181b55fae. View

Ferguson C, Hardy S, Werner D, Hileman S, DeLorey T, Homanics G . New insight into the role of the beta3 subunit of the GABAA-R in development, behavior, body weight regulation, and anesthesia revealed by conditional gene knockout. BMC Neurosci. 2007; 8:85. PMC: 2100059. DOI: 10.1186/1471-2202-8-85. View

Rau V, Oh I, Liao M, Bodarky C, Fanselow M, Homanics G . Gamma-aminobutyric acid type A receptor β3 subunit forebrain-specific knockout mice are resistant to the amnestic effect of isoflurane. Anesth Analg. 2011; 113(3):500-4. PMC: 4003562. DOI: 10.1213/ANE.0b013e3182273aff. View

Quintana A, Morgan P, Kruse S, Palmiter R, Sedensky M . Altered anesthetic sensitivity of mice lacking Ndufs4, a subunit of mitochondrial complex I. PLoS One. 2012; 7(8):e42904. PMC: 3422219. DOI: 10.1371/journal.pone.0042904. View

Hu F, Hanna G, Han W, Mardini F, Thomas S, Wyner A . Hypnotic hypersensitivity to volatile anesthetics and dexmedetomidine in dopamine β-hydroxylase knockout mice. Anesthesiology. 2012; 117(5):1006-17. PMC: 3628827. DOI: 10.1097/ALN.0b013e3182700ab9. View

10.

Solt K, Forman S . Correlating the clinical actions and molecular mechanisms of general anesthetics. Curr Opin Anaesthesiol. 2007; 20(4):300-6. DOI: 10.1097/ACO.0b013e32816678a5. View

11.

Franks N . General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal. Nat Rev Neurosci. 2008; 9(5):370-86. DOI: 10.1038/nrn2372. View

12.

Zhou C, Douglas J, Kumar N, Shu S, Bayliss D, Chen X . Forebrain HCN1 channels contribute to hypnotic actions of ketamine. Anesthesiology. 2013; 118(4):785-95. PMC: 3605219. DOI: 10.1097/ALN.0b013e318287b7c8. View

13.

Chen X, Shu S, Bayliss D . HCN1 channel subunits are a molecular substrate for hypnotic actions of ketamine. J Neurosci. 2009; 29(3):600-9. PMC: 2744993. DOI: 10.1523/JNEUROSCI.3481-08.2009. View

14.

Jurd R, Arras M, Lambert S, Drexler B, Siegwart R, Crestani F . General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit. FASEB J. 2002; 17(2):250-2. DOI: 10.1096/fj.02-0611fje. View