Dichlorination of Olefins with NCS/Ph(3)P
Overview
Chemistry
Affiliations
A 2 : 1 mixture of NCS and Ph(3)P successfully promoted the anti-dichlorination of olefins to provide corresponding dichlorides, serving as a molecular chlorine surrogate generated in situ.
Boshkow J, Fischer S, Bailey A, Wolfrum S, Carreira E Chem Sci. 2017; 8(10):6904-6910.
PMID: 29147515 PMC: 5632803. DOI: 10.1039/c7sc03124f.
Catalytic, Stereoselective Dihalogenation of Alkenes: Challenges and Opportunities.
Cresswell A, Eey S, Denmark S Angew Chem Int Ed Engl. 2015; 54(52):15642-82.
PMID: 26630449 PMC: 5072131. DOI: 10.1002/anie.201507152.
Catalytic, stereospecific syn-dichlorination of alkenes.
Cresswell A, Eey S, Denmark S Nat Chem. 2015; 7(2):146-52.
PMID: 25615668 PMC: 4674811. DOI: 10.1038/nchem.2141.