Catalytic Asymmetric Protonation of Silyl Ketene Imines

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2013 Feb 1

PMID 23362931

Citations 4

Authors

Joyram Guin

Georgy Varseev

Benjamin List

Affiliations

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Abstract

An efficient catalytic and highly enantioselective protonation of silyl ketene imines is described. The reaction is catalyzed by the chiral phosphoric acids TRIP or STRIP in the presence of a stoichiometric amount of methanol as the proton source and silyl acceptor. A variety of substituted racemic silyl ketene imines have been transformed into highly enantioenriched nitriles.

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