The Efficacy of the Inhalation of an Aerosolized Group A Streptococcal Preparation in the Treatment of Lung Cancer

Overview

Journal Chin J Cancer Res

Specialty Oncology

Date 2013 Jan 30

PMID 23359778

Citations 3

Authors

Jun Liu

Xiang Liu

Fei Cui

Guoqin Chen

Yubao Guan

Jianxing He

Affiliations

Soon will be listed here.

Abstract

Objective: To observe the efficacy of the inhalation of an aerosolized group A streptococcal (GAS) preparation in treating orthotopic lung cancer in mouse models and assess the feasibility, safety, and effectiveness of this administration mode for lung cancer.

Methods: Lewis lung carcinoma (LLC) cell strains were administered via intrathoracic injection to establish orthotopic lung cancer mouse models. After the tumor-bearing models were successfully established, as confirmed by computed tomography, the mice were administered by inhalation with an aerosolized GAS preparation (GAS group) or aerosolized normal saline (control group). The anti-tumor effect of the aerosolized GAS preparation was evaluated histologically; meanwhile, the survival and quality of life were compared between these two groups.

Results: The aerosolized GAS preparation showed remarkably anti-tumor effect, causing the necrosis of the orthotopic lung cancer cells in tumor-bearing mice. Furthermore, mice in the GAS group had significantly better quality of life and longer survival than those in control group.

Conclusions: The inhalation of aerosolized GAS preparation may be a feasible, safe and effective solution for lung cancer.

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References

Murala S, Alli V, Kreisel D, Gelman A, Krupnick A . Current status of immunotherapy for the treatment of lung cancer. J Thorac Dis. 2012; 2(4):237-44. PMC: 3256475. DOI: 10.3978/j.issn.2072-1439.2010.11.6. View

Zhou C, Manegold C . Chemotherapy of lung cancer: A global perspective of the role of ifosfamide. Transl Lung Cancer Res. 2015; 1(1):61-71. PMC: 4367585. DOI: 10.3978/j.issn.2218-6751.2011.12.02. View

Misaki T, Watanabe Y, Iida Y, Hidaka A, Kasagi K, Fukushima H . Recruitment of T lymphocytes and induction of tumor necrosis factor in thyroid cancer by a local immunotherapy. Cancer Immunol Immunother. 1992; 35(2):92-6. PMC: 11038611. DOI: 10.1007/BF01741855. View

Siegel R, Naishadham D, Jemal A . Cancer statistics, 2012. CA Cancer J Clin. 2012; 62(1):10-29. DOI: 10.3322/caac.20138. View

Labiris N, Dolovich M . Pulmonary drug delivery. Part I: physiological factors affecting therapeutic effectiveness of aerosolized medications. Br J Clin Pharmacol. 2003; 56(6):588-99. PMC: 1884307. DOI: 10.1046/j.1365-2125.2003.01892.x. View

Oshimi K, Kano S, Takaku F, Okumura K . Augmentation of mouse natural killer cell activity by a streptococcal preparation, OK-432. J Natl Cancer Inst. 1980; 65(6):1265-9. View

Winter H, van den Engel N, Rusan M, Schupp N, Poehlein C, Hu H . Active-specific immunotherapy for non-small cell lung cancer. J Thorac Dis. 2012; 3(2):105-14. PMC: 3256502. DOI: 10.3978/j.issn.2072-1439.2010.12.06. View

Luh K, Yang P, Kuo S, Chang D, Yu C, Lee L . Comparison of OK-432 and mitomycin C pleurodesis for malignant pleural effusion caused by lung cancer. A randomized trial. Cancer. 1992; 69(3):674-9. DOI: 10.1002/1097-0142(19920201)69:3<674::aid-cncr2820690313>3.0.co;2-5. View

Ichite N, Chougule M, Patel A, Jackson T, Safe S, Singh M . Inhalation delivery of a novel diindolylmethane derivative for the treatment of lung cancer. Mol Cancer Ther. 2010; 9(11):3003-14. PMC: 2978798. DOI: 10.1158/1535-7163.MCT-09-1104. View

10.

Liu X, Liu J, Guan Y, Li H, Huang L, Tang H . Establishment of an orthotopic lung cancer model in nude mice and its evaluation by spiral CT. J Thorac Dis. 2012; 4(2):141-5. PMC: 3378238. DOI: 10.3978/j.issn.2072-1439.2012.03.04. View

11.

Wang Z, Chen H, Roa W, Finlay W . Farnesol for aerosol inhalation: nebulization and activity against human lung cancer cells. J Pharm Pharm Sci. 2003; 6(1):95-100. View

12.

Voon P, Cho B, Yeo W, Soo R . The role of epidermal growth factor receptor tyrosine kinase inhibitors in the treatment of advanced stage non-small cell lung cancer. J Thorac Dis. 2012; 2(3):144-53. PMC: 3256457. DOI: 10.3978/j.issn.2072-1439.2010.02.03.6. View

13.

Park S, Zhu Y, Ozden O, Kim H, Jiang H, Deng C . SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis. Transl Cancer Res. 2012; 1(1):15-21. PMC: 3431025. View

14.

Pirker R, Filipits M . Cetuximab in non-small-cell lung cancer. Transl Lung Cancer Res. 2015; 1(1):54-60. PMC: 4367590. DOI: 10.3978/j.issn.2218-6751.11.01. View

15.

Okamoto H, SHOIN S, Koshimura S, Shimizu R . Studies on the anticancer and streptolysin S-forming abilities of hemolytic streptococci. Jpn J Microbiol. 1967; 11(4):323-6. DOI: 10.1111/j.1348-0421.1967.tb00350.x. View

16.

Wittgen B, Kunst P, van der Born K, van Wijk A, Perkins W, Pilkiewicz F . Phase I study of aerosolized SLIT cisplatin in the treatment of patients with carcinoma of the lung. Clin Cancer Res. 2007; 13(8):2414-21. DOI: 10.1158/1078-0432.CCR-06-1480. View

17.

Hojo H, Hashimoto Y . Cytotoxic cells induced in tumor-bearing rats by a streptococcus preparation (OK-432). Gan. 1981; 72(5):692-9. View

18.

Yang P, Xu X, Liu X, Gong J . The value of delayed (18)F FDG-PET imaging in diagnosis of solitary pulmonary nodules: A preliminary study on 28 patients. Quant Imaging Med Surg. 2012; 1(1):31-4. PMC: 3496491. DOI: 10.3978/j.issn.2223-4292.2011.11.03. View

19.

Li Y, Shi A, Li F, Yu R, Zhu G . Phase I Study to Determine MTD of Docetaxel and Cisplatin with Concurrent Radiation Therapy for Stage III Non-Small Cell Lung Cancer. Chin J Cancer Res. 2013; 23(2):129-33. PMC: 3587537. DOI: 10.1007/s11670-011-0129-9. View

20.

Hennon M, Demmy T . Video-assisted thoracoscopic surgery (VATS) for locally advanced lung cancer. Ann Cardiothorac Surg. 2013; 1(1):37-42. PMC: 3741708. DOI: 10.3978/j.issn.2225-319X.2012.03.05. View