Single-nucleotide Polymorphism Associations for Colorectal Cancer in Southern Chinese Population

Overview

Journal Chin J Cancer Res

Specialty Oncology

Date 2013 Jan 30

PMID 23359760

Citations 15

Authors

Fen-Xia Li

Xue-Xi Yang

Ni-Ya Hu

Hong-Yan Du

Qiang Ma

Ming Li

Affiliations

Soon will be listed here.

Abstract

Objective: Genome-wide association studies (GWAS) have identified 11 loci that influence the risk of developing colorectal cancer (CRC). Given that these studies were conducted in European Caucasian populations, it is not clear whether the results are relevant for populations with different ethnicities. The aim of this study was to examine these associations in a southern Chinese population.

Methods: Eleven single-nucleotide polymorphisms (SNPs), rs12701937, rs16892766, rs7014346, rs6983267, rs719725, rs10795668, rs3802842, rs4444235, rs9929218, rs10411210, and rs961253, were genotyped in 229 CRC patients and 267 controls using the MassArray SNP genotyping system.

Results: Evidence of an association with CRC was found for four of the 11 loci. The strongest associations were with rs4444235 and rs961253, with significant odds ratios close to those reported in previous GWAS. Among these four loci, rs719725 and rs4444235 were significantly associated with female gender, rs3802842, rs961253, and rs4444235 with early disease onset, and rs3802842 with later disease onset. However, no associations with CRC risk were detected for six other loci (rs9929218, rs10411210, rs12701937, rs7014346, rs6983267, and rs10795668), and one SNP, rs16892766, was not polymorphic in any of the study participants.

Conclusion: The rs4444235 and rs961253 loci are strongly associated with the risk of CRC in southern Chinese.

Citing Articles

Variation rs9929218 and risk of the colorectal Cancer and adenomas: A meta-analysis.

Wang H, Gu D, Yu M, Hu Y, Chen Z, Huo X BMC Cancer. 2021; 21(1):190.

PMID: 33627078 PMC: 7903630. DOI: 10.1186/s12885-021-07871-z.

Cumulative evidence of relationships between multiple variants in 8q24 region and cancer incidence.

Tong Y, Tang Y, Li S, Zhao F, Ying J, Qu Y Medicine (Baltimore). 2020; 99(26):e20716.

PMID: 32590746 PMC: 7328976. DOI: 10.1097/MD.0000000000020716.

Cumulative evidence for relationships between multiple variants in 8q24 and colorectal cancer incidence.

Tong Y, Wang H, Li S, Zhao F, Ying J, Qu Y Medicine (Baltimore). 2018; 97(35):e11990.

PMID: 30170403 PMC: 6392673. DOI: 10.1097/MD.0000000000011990.

Common genetic variant rs3802842 in 11q23 contributes to colorectal cancer risk in Chinese population.

Zhang C, Li X, Zhang W, Wang Y, Fan G, Wang W Oncotarget. 2017; 8(42):72227-72234.

PMID: 29069782 PMC: 5641125. DOI: 10.18632/oncotarget.19702.

Association between 8q24 rs6983267 polymorphism and cancer susceptibility: a meta-analysis involving 170,737 subjects.

Zhu M, Wen X, Liu X, Wang Y, Liang C, Tu J Oncotarget. 2017; 8(34):57421-57439.

PMID: 28915683 PMC: 5593654. DOI: 10.18632/oncotarget.18960.

References

Houlston R, Webb E, Broderick P, Pittman A, Di Bernardo M, Lubbe S . Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. Nat Genet. 2008; 40(12):1426-35. PMC: 2836775. DOI: 10.1038/ng.262. View

Zanke B, Greenwood C, Rangrej J, Kustra R, Tenesa A, Farrington S . Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24. Nat Genet. 2007; 39(8):989-94. DOI: 10.1038/ng2089. View

Pittman A, Webb E, Carvajal-Carmona L, Howarth K, Di Bernardo M, Broderick P . Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer. Hum Mol Genet. 2008; 17(23):3720-7. DOI: 10.1093/hmg/ddn267. View

Xiong F, Wu C, Bi X, Yu D, Huang L, Xu J . Risk of genome-wide association study-identified genetic variants for colorectal cancer in a Chinese population. Cancer Epidemiol Biomarkers Prev. 2010; 19(7):1855-61. DOI: 10.1158/1055-9965.EPI-10-0210. View

Tomlinson I, Webb E, Carvajal-Carmona L, Broderick P, Howarth K, Pittman A . A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. Nat Genet. 2008; 40(5):623-30. DOI: 10.1038/ng.111. View

Kupfer S, Anderson J, Hooker S, Skol A, Kittles R, Keku T . Genetic heterogeneity in colorectal cancer associations between African and European americans. Gastroenterology. 2010; 139(5):1677-85, 1685.e1-8. PMC: 3721963. DOI: 10.1053/j.gastro.2010.07.038. View

Kim J, Crooks H, Dracheva T, Nishanian T, Singh B, Jen J . Oncogenic beta-catenin is required for bone morphogenetic protein 4 expression in human cancer cells. Cancer Res. 2002; 62(10):2744-8. View

Poynter J, Figueiredo J, Conti D, Kennedy K, Gallinger S, Siegmund K . Variants on 9p24 and 8q24 are associated with risk of colorectal cancer: results from the Colon Cancer Family Registry. Cancer Res. 2007; 67(23):11128-32. DOI: 10.1158/0008-5472.CAN-07-3239. View

Tomlinson I, Webb E, Carvajal-Carmona L, Broderick P, Kemp Z, Spain S . A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21. Nat Genet. 2007; 39(8):984-8. DOI: 10.1038/ng2085. View

10.

Middeldorp A, Jagmohan-Changur S, van Eijk R, Tops C, Devilee P, Vasen H . Enrichment of low penetrance susceptibility loci in a Dutch familial colorectal cancer cohort. Cancer Epidemiol Biomarkers Prev. 2009; 18(11):3062-7. DOI: 10.1158/1055-9965.EPI-09-0601. View

11.

Ho J, Choi S, Lee Y, Hui T, Cherny S, Garcia-Barcelo M . Replication study of SNP associations for colorectal cancer in Hong Kong Chinese. Br J Cancer. 2010; 104(2):369-75. PMC: 3031883. DOI: 10.1038/sj.bjc.6605977. View

12.

Curtin K, Lin W, George R, Katory M, Shorto J, Cannon-Albright L . Meta association of colorectal cancer confirms risk alleles at 8q24 and 18q21. Cancer Epidemiol Biomarkers Prev. 2009; 18(2):616-21. PMC: 2729170. DOI: 10.1158/1055-9965.EPI-08-0690. View

13.

Lascorz J, Forsti A, Chen B, Buch S, Steinke V, Rahner N . Genome-wide association study for colorectal cancer identifies risk polymorphisms in German familial cases and implicates MAPK signalling pathways in disease susceptibility. Carcinogenesis. 2010; 31(9):1612-9. DOI: 10.1093/carcin/bgq146. View

14.

He X, Zhang J, Tong W, Tawfik O, Ross J, Scoville D . BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling. Nat Genet. 2004; 36(10):1117-21. DOI: 10.1038/ng1430. View

15.

. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature. 2007; 447(7145):661-78. PMC: 2719288. DOI: 10.1038/nature05911. View

16.

Cheah P . Recent advances in colorectal cancer genetics and diagnostics. Crit Rev Oncol Hematol. 2008; 69(1):45-55. DOI: 10.1016/j.critrevonc.2008.08.001. View

17.

Tenesa A, Farrington S, Prendergast J, Porteous M, Walker M, Haq N . Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nat Genet. 2008; 40(5):631-7. PMC: 2778004. DOI: 10.1038/ng.133. View

18.

Wijnen J, Brohet R, van Eijk R, Jagmohan-Changur S, Middeldorp A, Tops C . Chromosome 8q23.3 and 11q23.1 variants modify colorectal cancer risk in Lynch syndrome. Gastroenterology. 2008; 136(1):131-7. DOI: 10.1053/j.gastro.2008.09.033. View

19.

Matsuo K, Suzuki T, Ito H, Hosono S, Kawase T, Watanabe M . Association between an 8q24 locus and the risk of colorectal cancer in Japanese. BMC Cancer. 2009; 9:379. PMC: 2783039. DOI: 10.1186/1471-2407-9-379. View

20.

von Holst S, Picelli S, Edler D, Lenander C, Dalen J, Hjern F . Association studies on 11 published colorectal cancer risk loci. Br J Cancer. 2010; 103(4):575-80. PMC: 2939779. DOI: 10.1038/sj.bjc.6605774. View