Motivational Enhancement System for Adherence (MESA): Pilot Randomized Trial of a Brief Computer-delivered Prevention Intervention for Youth Initiating Antiretroviral Treatment

Overview

Journal J Pediatr Psychol

Publisher Oxford University Press

Date 2013 Jan 30

PMID 23359664

Citations 55

Authors

Sylvie Naar-King

Angulique Y Outlaw

Moussa Sarr

Jeffrey T Parsons

Marvin Belzer

Karen MacDonell

Mary Tanney

Steven J Ondersma

Affiliations

Soon will be listed here.

Abstract

Objective: To pilot test a two-session computer-delivered motivational intervention to facilitate adherence among youth with HIV newly prescribed antiretroviral treatment (ART).

Methods: Youth (N = 76) newly prescribed ART were recruited from 8 sites, and were randomized to the intervention or an active nutrition and physical activity control. Primary outcomes were HIV-1 viral load at baseline, 3 months, and 6 months, and self-reported adherence at 3 and 6 months.

Results: Satisfaction ratings were high. Effect sizes suggested that the intervention group showed a greater drop than controls in viral load from baseline to 6 months (Cohen's d = 0.39 at 3 months; d = 0.19 at 6 months), and had greater percent undetectable by 6 months (d = 0.28). Effects sizes were medium to large for 7-day and weekend adherence.

Conclusions: A brief computer-delivered motivational intervention showed promise for youth starting ART and is ready to be tested in a full-scale clinical trial.

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