Typical Cell Signaling Response to Ionizing Radiation: DNA Damage and Extranuclear Damage

Overview

Journal Chin J Cancer Res

Specialty Oncology

Date 2013 Jan 30

PMID 23357898

Citations 17

Authors

Hui Yu

Affiliations

Soon will be listed here.

Abstract

To treat many types of cancer, ionizing radiation (IR) is primarily used as external-beam radiotherapy, brachytherapy, and targeted radionuclide therapy. Exposure of tumor cells to IR can induce DNA damage as well as generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) which can cause non-DNA lesions or extracellular damage like lipid perioxidation. The initial radiation-induced cell responses to DNA damage and ROS like the proteolytic processing, as well as synthesis and releasing ligands (such as growth factors, cytokines, and hormone) can cause the delayed secondary responses in irradiated and unirradiated bystander cells through paracrine and autocrine pathways.

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