Mixed Vaginitis-more Than Coinfection and with Therapeutic Implications

Overview

Journal Curr Infect Dis Rep

Specialty Infectious Diseases

Date 2013 Jan 29

PMID 23354954

Citations 32

Authors

Jack D Sobel

Chitra Subramanian

Betsy Foxman

Marilyn Fairfax

Scott E Gygax

Affiliations

Soon will be listed here.

Abstract

Mixed vaginitis is due to the simultaneous presence of at least two vaginal pathogens, both contributing to an abnormal vaginal milieu and, hence, symptoms and signs of vaginitis. In mixed vaginitis, both pathogens require specific therapy for complete eradication of concurrent manifestations. In coinfection, although two pathogens are identified, a potential pathogen may be present but may not be a cause of existing vaginal symptoms. Although data remain sparse, mixed vaginitis occurs rarely (<5 %). By contrast, pathogen coinfection occurs frequently in women with vaginitis. Approximately 20 %-30 % of women with bacterial vaginosis (BV) are coinfected with Candida species. Coexistence of BV pathogens and T. vaginalis is even more common, with coinfection rates of 60 %-80 %. Both coinfection and mixed vaginitis have significant clinical and therapeutic implications and are worthy of further investigation.

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