Induction of the SOS Response in Ultraviolet-Irradiated Escherichia Coli Analyzed by Dynamics of LexA, RecA and SulA Proteins

Overview

Journal J Biol Phys

Specialty Biophysics

Date 2013 Jan 25

PMID 23345702

Citations 10

Authors

S V Aksenov

Affiliations

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Abstract

The SOS response in Escherichia coli is induced after DNA-damaging treatments including ultraviolet light. Regulation of the SOS response is accomplished through specific interaction of the two SOS regulator proteins, LexA and RecA. In ultraviolet light-treated cells, nucleotide excision repair is the major system that removes the induced lesions from the DNA. Here, induction of the SOS response in Escherichia coli with normal and impaired excision repair function is studied by simulation of intracellular levels of regulatory LexA and RecA proteins, and SulA protein. SulA protein is responsible for SOS-inducible cell division inhibition. Results of the simulations show that nucleotide excision repair influences time-courses of LexA, RecA and SulA induction by modulating the dynamics of RecA protein distribution between its normal and SOS-activated forms.

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