Relation of Neutrophil to Lymphocyte Ratio with the Presence and Severity of Stable Coronary Artery Disease

Overview

Journal Clin Appl Thromb Hemost

Publisher Sage Publications

Specialty Cardiology & Vascular Diseases

Date 2013 Jan 25

PMID 23344996

Citations 19

Authors

Ahmet Kaya

Mustafa Kurt

Ibrahim Halil Tanboga

Turgay Isik

Zeki Yuksel Gunaydin

Yasemin Kaya

Selim Topcu

Serdar Sevimli

Affiliations

Soon will be listed here.

Abstract

Objectives: We examined the association between neutrophil to lymphocyte ratio (NLR) and the complexity of coronary artery disease assessed by SYNTAX score (SS).

Methods: The study population included patients with chest pain who had undergone coronary angiography for stable angina pectoris. Patients were classified depending on whether the SS was 0 or SS > 0.

Results: Left ventricular ejection fraction, estimated glomerular filtration rate, and NLR were found to be the independent predictors of high SS in multivariate analysis. The area under the receiver-operating curve of NLR was 0.72 (0.65-0.80, P < .001) for predicting high SS. The optimal cutoff value of NLR to predict high SS was 2.7 (sensitivity of 72% and a specificity of 61%). There was a significant correlation between NLR ratio and continuous SS (r = .552, P < .001).

Conclusion: The NLR is a readily measurable systemic inflammatory marker and is associated with both the presence and the complexity of coronary artery disease.

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