Risk Factors for Neurologic Complications of Hand, Foot and Mouth Disease in the Republic of Korea, 2009

Overview

Journal J Korean Med Sci

Specialty General Medicine

Date 2013 Jan 24

PMID 23341722

Citations 24

Authors

Seong Joon Kim

Jong-Hyun Kim

Jin-Han Kang

Dong Soo Kim

Ki Hwan Kim

Kyung-Hyo Kim

Young-Hoon Kim

Ju-Young Chung

Joong Hyun Bin

Da Eun Jung

Ji Hong Kim

Hwang Min Kim

Doo-Sung Cheon

Byung Hak Kang

Soon Young Seo

Affiliations

Soon will be listed here.

Abstract

In 2009, the first outbreak of hand, foot and mouth disease (HFMD) or herpangina (HP) caused by enterovirus 71 occurred in the Republic of Korea. This study inquired into risk factors associated with complications of HFMD or HP. A retrospective medical records review was conducted on HFMD or HP patients for whom etiologic viruses had been verified in 2009. One hundred sixty-eight patients were examined for this investigation. Eighty patients were without complications while 88 were accompanied by complications, and 2 had expired. Enterovirus 71 subgenotype C4a was the most prevalent in number with 67 cases (54.9%). In the univariate analysis, the disease patterns of HFMD rather than HP, fever longer than 4 days, peak body temperature over 39℃, vomiting, headache, neurologic signs, serum glucose over 100 mg/dL, and having an enterovirus 71 as a causative virus were significant risk factors of the complications. After multiple logistic analysis, headache (Odds ratio [OR], 10.75; P < 0.001) and neurologic signs (OR, 42.76; P < 0.001) were found to be the most significant factors. Early detection and proper management of patients with aforementioned risk factors would be necessary in order to attain a better clinical outcome.

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