The NuRD Architecture

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2013 Jan 24

PMID 23340908

Citations 107

Authors

Hillary F Allen

Paul A Wade

Tatiana G Kutateladze

Affiliations

Soon will be listed here.

Abstract

The nucleosome remodeling and deacetylase (NuRD) complex regulates chromatin organization, gene transcription, genomic stability and developmental signaling. NuRD has a unique dual enzymatic activity, containing an ATPase and a histone deacetylase among its six core subunits. Recent studies indicate that NuRD composition and the interplay between subunits may dictate the diverse functions of the complex. In this review, we examine the structures and biological roles of the NuRD subunits and discuss new avenues of research to advance our understanding of the NuRD-mediated signaling network.

Citing Articles

Nucleosome wrapping states encode principles of 3D genome organization.

Wen Z, Fang R, Zhang R, Yu X, Zhou F, Long H Nat Commun. 2025; 16(1):352.

PMID: 39753536 PMC: 11699143. DOI: 10.1038/s41467-024-54735-8.

SP140 represses specific loci by recruiting polycomb repressive complex 2 and NuRD complex.

Tamburri S, Zucchelli C, Matafora V, Zapparoli E, Jevtic Z, Farris F Nucleic Acids Res. 2024; 53(4).

PMID: 39718989 PMC: 11879014. DOI: 10.1093/nar/gkae1215.

DNA-binding proteins from MBD through ZF to BEN: recognition of cytosine methylation status by one arginine with two conformations.

Zhang X, Blumenthal R, Cheng X Nucleic Acids Res. 2024; 52(19):11442-11454.

PMID: 39329271 PMC: 11514455. DOI: 10.1093/nar/gkae832.

The GATAD2B-NuRD complex drives DNA:RNA hybrid-dependent chromatin boundary formation upon DNA damage.

Liu Z, Ajit K, Wu Y, Zhu W, Gullerova M EMBO J. 2024; 43(12):2453-2485.

PMID: 38719994 PMC: 11183058. DOI: 10.1038/s44318-024-00111-7.

CARM1 hypermethylates the NuRD chromatin remodeling complex to promote cell cycle gene expression and breast cancer development.

Chen X, Huang M, Fan D, He Y, Zhang W, Ding J Nucleic Acids Res. 2024; 52(12):6811-6829.

PMID: 38676947 PMC: 11229315. DOI: 10.1093/nar/gkae329.

References

Brehm A, Nielsen S, Miska E, McCance D, Reid J, Bannister A . The E7 oncoprotein associates with Mi2 and histone deacetylase activity to promote cell growth. EMBO J. 1999; 18(9):2449-58. PMC: 1171327. DOI: 10.1093/emboj/18.9.2449. View

Lai A, Wade P . Cancer biology and NuRD: a multifaceted chromatin remodelling complex. Nat Rev Cancer. 2011; 11(8):588-96. PMC: 4157524. DOI: 10.1038/nrc3091. View

Blus B, Wiggins K, Khorasanizadeh S . Epigenetic virtues of chromodomains. Crit Rev Biochem Mol Biol. 2011; 46(6):507-26. PMC: 3223283. DOI: 10.3109/10409238.2011.619164. View

Larsen D, Poinsignon C, Gudjonsson T, Dinant C, Payne M, Hari F . The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage. J Cell Biol. 2010; 190(5):731-40. PMC: 2935572. DOI: 10.1083/jcb.200912135. View

Toh Y, Pencil S, Nicolson G . A novel candidate metastasis-associated gene, mta1, differentially expressed in highly metastatic mammary adenocarcinoma cell lines. cDNA cloning, expression, and protein analyses. J Biol Chem. 1994; 269(37):22958-63. View

Ge Q, Nilasena D, OBrien C, FRANK M, Targoff I . Molecular analysis of a major antigenic region of the 240-kD protein of Mi-2 autoantigen. J Clin Invest. 1995; 96(4):1730-7. PMC: 185809. DOI: 10.1172/JCI118218. View

Yarden R, Brody L . BRCA1 interacts with components of the histone deacetylase complex. Proc Natl Acad Sci U S A. 1999; 96(9):4983-8. PMC: 21803. DOI: 10.1073/pnas.96.9.4983. View

Mansfield R, Musselman C, Kwan A, Oliver S, Garske A, Davrazou F . Plant homeodomain (PHD) fingers of CHD4 are histone H3-binding modules with preference for unmodified H3K4 and methylated H3K9. J Biol Chem. 2011; 286(13):11779-91. PMC: 3064229. DOI: 10.1074/jbc.M110.208207. View

Zhang Y, Leroy G, Seelig H, Lane W, Reinberg D . The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities. Cell. 1998; 95(2):279-89. DOI: 10.1016/s0092-8674(00)81758-4. View

10.

Wade P, Gegonne A, Jones P, Ballestar E, Aubry F, Wolffe A . Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation. Nat Genet. 1999; 23(1):62-6. DOI: 10.1038/12664. View

11.

Segre C, Chiocca S . Regulating the regulators: the post-translational code of class I HDAC1 and HDAC2. J Biomed Biotechnol. 2011; 2011:690848. PMC: 3004424. DOI: 10.1155/2011/690848. View

12.

Murawsky C, Brehm A, Badenhorst P, Lowe N, Becker P, Travers A . Tramtrack69 interacts with the dMi-2 subunit of the Drosophila NuRD chromatin remodelling complex. EMBO Rep. 2001; 2(12):1089-94. PMC: 1084170. DOI: 10.1093/embo-reports/kve252. View

13.

Gao H, Lukin K, Ramirez J, Fields S, Lopez D, Hagman J . Opposing effects of SWI/SNF and Mi-2/NuRD chromatin remodeling complexes on epigenetic reprogramming by EBF and Pax5. Proc Natl Acad Sci U S A. 2009; 106(27):11258-63. PMC: 2708696. DOI: 10.1073/pnas.0809485106. View

14.

Kwan A, Gell D, Verger A, Crossley M, Matthews J, Mackay J . Engineering a protein scaffold from a PHD finger. Structure. 2003; 11(7):803-13. DOI: 10.1016/s0969-2126(03)00122-9. View

15.

Murzina N, Pei X, Zhang W, Sparkes M, Vicente-Garcia J, Pratap J . Structural basis for the recognition of histone H4 by the histone-chaperone RbAp46. Structure. 2008; 16(7):1077-85. PMC: 2572730. DOI: 10.1016/j.str.2008.05.006. View

16.

Li D, Ohshiro K, Reddy S, Pakala S, Lee M, Zhang Y . E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1. Proc Natl Acad Sci U S A. 2009; 106(41):17493-8. PMC: 2762678. DOI: 10.1073/pnas.0908027106. View

17.

Johnson D, Lovett J, Hirsch M, Xia F, Chen J . NuRD complex component Mi-2beta binds to and represses RORgamma-mediated transcriptional activation. Biochem Biophys Res Commun. 2004; 318(3):714-8. DOI: 10.1016/j.bbrc.2004.04.087. View

18.

Fasulo B, Deuring R, Murawska M, Gause M, Dorighi K, Schaaf C . The Drosophila MI-2 chromatin-remodeling factor regulates higher-order chromatin structure and cohesin dynamics in vivo. PLoS Genet. 2012; 8(8):e1002878. PMC: 3415455. DOI: 10.1371/journal.pgen.1002878. View

19.

Fujita N, Jaye D, Geigerman C, Akyildiz A, Mooney M, Boss J . MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation. Cell. 2004; 119(1):75-86. DOI: 10.1016/j.cell.2004.09.014. View

20.

Zegerman P, Canas B, Pappin D, Kouzarides T . Histone H3 lysine 4 methylation disrupts binding of nucleosome remodeling and deacetylase (NuRD) repressor complex. J Biol Chem. 2002; 277(14):11621-4. DOI: 10.1074/jbc.C200045200. View