Interferon γ in Patients with HIV/AIDS and Suspicion or Latent Tuberculosis Infection

Overview

Journal Asian Pac J Trop Med

Specialties Infectious Diseases
Tropical Medicine

Date 2013 Jan 24

PMID 23339916

Citations 3

Authors

Guadalupe Garcia-Elorriaga

Mayte Martinez-Velazquez

Veronica Gaona-Flores

Guillermo Del Rey-Pineda

Cesar Gonzalez-Bonilla

Affiliations

Soon will be listed here.

Abstract

Objective: To assess the usefulness of IGRA test (QuantiFERON(®)-Cell mediated immune) compared with the tuberculin skin test.

Methods: A cross-sectional study was carried out in Mexico, 25 infected patients with HIV-AIDS and the suspicion or with latent tuberculous infection (LTBI) who were >18 years of age and without treatment for tuberculosis (TB), were enrolled in the study.

Results: Median cluster of differentiation (CD4) count was 364 cells/μ L and median HIV viral load was 50 copies/mL. Overall, 20 patients (80%) had at least one positive diagnostic test for LTBI: four (16%) had a positive tuberculin skin test and 19 (76%), a positive QuantiFERON(®)-tuberculosis.

Conclusions: No agreement is found between the two diagnostic tests: k = -0.004, 95% confidence interval (-0.2219, 0.2210). Additional longitudinal studies among HIV-infected populations with high prevalence of TB are needed to further assess the usefulness of IGRAs in this patient population.

Citing Articles

Diagnostic accuracy of the interferon-gamma release assay in acquired immunodeficiency syndrome patients with suspected tuberculosis infection: a meta-analysis.

Chen H, Nakagawa A, Takamori M, Abe S, Ueno D, Horita N Infection. 2022; 50(3):597-606.

PMID: 35249210 PMC: 9151521. DOI: 10.1007/s15010-022-01789-9.

The Clinical Usefulness of Tuberculin Skin Test versus Interferon-Gamma Release Assays for Diagnosis of Latent Tuberculosis in HIV Patients: A Meta-Analysis.

Ayubi E, Doosti-Irani A, Moghaddam A, Sani M, Nazarzadeh M, Mostafavi E PLoS One. 2016; 11(9):e0161983.

PMID: 27622293 PMC: 5021339. DOI: 10.1371/journal.pone.0161983.

Interferon-gamma release assay versus tuberculin skin test for latent tuberculosis infection among HIV patients in Brazil.

Kussen G, Dalla-Costa L, Rossoni A, Raboni S Braz J Infect Dis. 2015; 20(1):69-75.

PMID: 26706018 PMC: 9425390. DOI: 10.1016/j.bjid.2015.10.007.