Breaking Barriers to an AIDS Model with Macaque-Tropic HIV-1 Derivatives

Overview

Journal Biology (Basel)

Publisher MDPI

Specialty Biology

Date 2013 Jan 22

PMID 23336082

Citations 12

Authors

Rajesh Thippeshappa

Hongmei Ruan

Jason T Kimata

Affiliations

Soon will be listed here.

Abstract

The development of an animal model of human immunodeficiency virus type 1 (HIV-1)/AIDS that is suitable for preclinical testing of antiretroviral therapy, vaccines, curative strategies, and studies of pathogenesis has been hampered by the human-specific tropism of HIV-1. Although simian immunodeficiency virus (SIV) or HIV-1/SIV chimeric viruses (SHIVs)-rhesus macaque models are excellent surrogates for AIDS research, the genetic differences between SIV or SHIV and HIV-1 limit their utility as model systems. The identification of innate retro viral restriction factors has increased our understanding about blockades to HIV-1 replication in macaques and provided a guide for the construction of macaque-tropic HIV-1 clones. However, while these viruses replicate in macaque cells in vitro, they are easily controlled and have not caused AIDS in host animals, indicating that we may not fully understand the restrictive barriers of innate immunity. In this review, we discuss recent findings regarding HIV-1 restriction factors, particularly as they apply to cross-species transmission of primate lentiviruses and the development of a macaque model of HIV-1/AIDS.

Citing Articles

Humanized Mice for Studies of HIV-1 Persistence and Elimination.

Zhang C, Zaman L, Poluektova L, Gorantla S, Gendelman H, Dash P Pathogens. 2023; 12(7).

PMID: 37513726 PMC: 10383313. DOI: 10.3390/pathogens12070879.

Productive Replication of HIV-1 but Not SIVmac in Small Ruminant Cells.

Chergui H, Idres T, Chaudesaigues C, Noueihed D, Gagnon J, Chebloune Y Pathogens. 2022; 11(7).

PMID: 35890043 PMC: 9316499. DOI: 10.3390/pathogens11070799.

Serial Passaging of Human-Simian Immunodeficiency Virus Clones Identifies Characteristics for Persistent Viral Replication.

Thippeshappa R, Polacino P, Chandrasekar S, Truong K, Misra A, Aulicino P Front Microbiol. 2021; 12:779460.

PMID: 34867922 PMC: 8636705. DOI: 10.3389/fmicb.2021.779460.

Commentary: Derivation of Simian Tropic HIV-1 Infectious Clone Reveals Virus Adaptation to a New Host.

Adachi A, Koma T, Doi N, Nomaguchi M Front Cell Infect Microbiol. 2020; 10:235.

PMID: 32500043 PMC: 7243179. DOI: 10.3389/fcimb.2020.00235.

Toward a Macaque Model of HIV-1 Infection: Roadblocks, Progress, and Future Strategies.

Thippeshappa R, Kimata J, Kaushal D Front Microbiol. 2020; 11:882.

PMID: 32477302 PMC: 7237640. DOI: 10.3389/fmicb.2020.00882.

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