GABA-B Receptors in the PNS Have a Role in Schwann Cells Differentiation?

Overview

Journal Front Cell Neurosci

Specialty Cell Biology

Date 2013 Jan 22

PMID 23335881

Citations 19

Authors

Patrizia Procacci

Marinella Ballabio

Luca F Castelnovo

Cristina Mantovani

Valerio Magnaghi

Affiliations

Soon will be listed here.

Abstract

γ-aminobutyric acid type B (GABA-B) receptor mediates the inhibitory transmission of γ-aminobutyric acid in the mammalian nervous system, being present in neurons and also in glial cells. Recently the presence of GABA-B has been demonstrated in Schwann cells (SC) suggesting its contribution in regulating the cell fate, maturation, and plasticity. Here, we further support the functional presence of GABA-B receptor in SC plasma membrane. By confocal microscopy immunofluorescence we provide evidences that GABA-B localization on the cell elongated processes correlates with the morphological changes occurring in the differentiated SC. In vivo most of the GABA-B receptors seem to be present in non-myelinating SC, which are committed to ensheath the nociceptive fibers. Therefore, we argue that GABA-B receptors do not control exclusively the in vivo differentiation yielding the myelinating SC, but are also fundamental in regulating the SC plasticity versus the non-myelinating state. Data from the literature and our recent findings corroborate the role of the GABAergic system and GABA-B receptors in the peripheral nervous system, opening new perspectives on the mechanisms controlling the differentiation of SC.

Citing Articles

Development and In Vitro Differentiation of Schwann Cells.

Horner S, Couturier N, Gueiber D, Hafner M, Rudolf R Cells. 2022; 11(23).

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Peripheral mechanisms of chronic pain.

Zheng Q, Dong X, Green D, Dong X Med Rev (2021). 2022; 2(3):251-270.

PMID: 36067122 PMC: 9381002. DOI: 10.1515/mr-2022-0013.

Peripheral glia diversity.

Reed C, Feltri M, Wilson E J Anat. 2021; 241(5):1219-1234.

PMID: 34131911 PMC: 8671569. DOI: 10.1111/joa.13484.

Expression and Function of GABA Receptors in Myelinating Cells.

Serrano-Regal M, Bayon-Cordero L, Ordaz R, Garay E, Limon A, Arellano R Front Cell Neurosci. 2020; 14:256.

PMID: 32973453 PMC: 7472887. DOI: 10.3389/fncel.2020.00256.

Schwann cell interactions during the development of the peripheral nervous system.

Wilson E, Della-Flora Nunes G, Weaver M, Frick L, Feltri M Dev Neurobiol. 2020; 81(5):464-489.

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