Bergmann Glia Function in Granule Cell Migration During Cerebellum Development

Overview

Journal Mol Neurobiol

Specialties Molecular Biology
Neurology

Date 2013 Jan 19

PMID 23329344

Citations 39

Authors

Haiwei Xu

Yang Yang

Xiaotong Tang

Meina Zhao

Fucheng Liang

Pei Xu

Baoke Hou

Yan Xing

Xiaohang Bao

Xiaotang Fan

Affiliations

Soon will be listed here.

Abstract

Granule cell migration influences the laminar structure of the cerebellum and thereby affects cerebellum function. Bergmann glia are derived from radial glial cells and aid in granule cell radial migration by providing a scaffold for migration and by mediating interactions between Bergmann glia and granule cells. In this review, we summarize Bergmann glia characteristics and the mechanisms underlying the effect of Bergmann glia on the radial migration of granule neurons in the cerebellum. Furthermore, we will focus our discussion on the important factors involved in glia-mediated radial migration so that we may elucidate the possible mechanistic pathways used by Bergmann glia to influence granule cell migration during cerebellum development.

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References

Eiraku M, Tohgo A, Ono K, Kaneko M, Fujishima K, Hirano T . DNER acts as a neuron-specific Notch ligand during Bergmann glial development. Nat Neurosci. 2005; 8(7):873-80. DOI: 10.1038/nn1492. View

Stevens H, Smith K, Maragnoli M, Fagel D, Borok E, Shanabrough M . Fgfr2 is required for the development of the medial prefrontal cortex and its connections with limbic circuits. J Neurosci. 2010; 30(16):5590-602. PMC: 2868832. DOI: 10.1523/JNEUROSCI.5837-09.2010. View

Kim P, Aizawa H, Kim P, Huang A, Wickramasinghe S, Kashani A . Serine racemase: activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration. Proc Natl Acad Sci U S A. 2005; 102(6):2105-10. PMC: 548584. DOI: 10.1073/pnas.0409723102. View

Lindner J, Rathjen F, Schachner M . L1 mono- and polyclonal antibodies modify cell migration in early postnatal mouse cerebellum. Nature. 1983; 305(5933):427-30. DOI: 10.1038/305427a0. View

Altman J, Bayer S . Prenatal development of the cerebellar system in the rat. I. Cytogenesis and histogenesis of the deep nuclei and the cortex of the cerebellum. J Comp Neurol. 1978; 179(1):23-48. DOI: 10.1002/cne.901790104. View

Edwards M, Yamamoto M, Caviness Jr V . Organization of radial glia and related cells in the developing murine CNS. An analysis based upon a new monoclonal antibody marker. Neuroscience. 1990; 36(1):121-44. DOI: 10.1016/0306-4522(90)90356-9. View

Shiga T, Ichikawa M, Hirata Y . A Golgi study of Bergmann glial cells in developing rat cerebellum. Anat Embryol (Berl). 1983; 167(2):191-201. DOI: 10.1007/BF00298510. View

Qiu Z, Cang Y, Goff S . Abl family tyrosine kinases are essential for basement membrane integrity and cortical lamination in the cerebellum. J Neurosci. 2010; 30(43):14430-9. PMC: 3842486. DOI: 10.1523/JNEUROSCI.2861-10.2010. View

Volpe J, Adams R . Cerebro-hepato-renal syndrome of Zellweger: an inherited disorder of neuronal migration. Acta Neuropathol. 1972; 20(3):175-98. DOI: 10.1007/BF00686900. View

10.

Gimenez y Ribotta M, Langa F, Menet V, Privat A . Comparative anatomy of the cerebellar cortex in mice lacking vimentin, GFAP, and both vimentin and GFAP. Glia. 2000; 31(1):69-83. DOI: 10.1002/(sici)1098-1136(200007)31:1<69::aid-glia70>3.0.co;2-w. View

11.

Koirala S, Corfas G . Identification of novel glial genes by single-cell transcriptional profiling of Bergmann glial cells from mouse cerebellum. PLoS One. 2010; 5(2):e9198. PMC: 2820553. DOI: 10.1371/journal.pone.0009198. View

12.

Komuro H, Yacubova E, Rakic P . Mode and tempo of tangential cell migration in the cerebellar external granular layer. J Neurosci. 2001; 21(2):527-40. PMC: 6763794. View

13.

Voogd J, Glickstein M . The anatomy of the cerebellum. Trends Cogn Sci. 2011; 2(9):307-13. DOI: 10.1016/s1364-6613(98)01210-8. View

14.

Chen Y, Collins L, Chang S, Chang C . The roles of testicular orphan nuclear receptor 4 (TR4) in cerebellar development. Cerebellum. 2008; 7(1):9-17. DOI: 10.1007/s12311-008-0006-3. View

15.

Morte B, Manzano J, Scanlan T, Vennstrom B, Bernal J . Aberrant maturation of astrocytes in thyroid hormone receptor alpha 1 knockout mice reveals an interplay between thyroid hormone receptor isoforms. Endocrinology. 2003; 145(3):1386-91. DOI: 10.1210/en.2003-1123. View

16.

Portella A, Carvalho F, Faustino L, Wondisford F, Ortiga-Carvalho T, Gomes F . Thyroid hormone receptor beta mutation causes severe impairment of cerebellar development. Mol Cell Neurosci. 2010; 44(1):68-77. DOI: 10.1016/j.mcn.2010.02.004. View

17.

Martinez R, Eller C, Viana N, Gomes F . Thyroid hormone induces cerebellar neuronal migration and Bergmann glia differentiation through epidermal growth factor/mitogen-activated protein kinase pathway. Eur J Neurosci. 2010; 33(1):26-35. DOI: 10.1111/j.1460-9568.2010.07490.x. View

18.

Chen Y, Collins L, Uno H, Chang C . Deficits in motor coordination with aberrant cerebellar development in mice lacking testicular orphan nuclear receptor 4. Mol Cell Biol. 2005; 25(7):2722-32. PMC: 1061629. DOI: 10.1128/MCB.25.7.2722-2732.2005. View

19.

Hatten M, Mason C . Mechanisms of glial-guided neuronal migration in vitro and in vivo. Experientia. 1990; 46(9):907-16. DOI: 10.1007/BF01939383. View

20.

Toda T, Kobayashi K, Takeda S, Sasaki J, Kurahashi H, Kano H . Fukuyama-type congenital muscular dystrophy (FCMD) and alpha-dystroglycanopathy. Congenit Anom (Kyoto). 2003; 43(2):97-104. DOI: 10.1111/j.1741-4520.2003.tb01033.x. View