Innate Sensing of Chitin and Chitosan

Overview

Journal PLoS Pathog

Specialty Microbiology

Date 2013 Jan 18

PMID 23326227

Citations 78

Authors

Chelsea L Bueter

Charles A Specht

Stuart M Levitz

Affiliations

Soon will be listed here.

Citing Articles

Chitosan immunomodulation: insights into mechanisms of action on immune cells and signaling pathways.

Ghattas M, Dwivedi G, Chevrier A, Horn-Bourque D, Alameh M, Lavertu M RSC Adv. 2025; 15(2):896-909.

PMID: 39802469 PMC: 11719903. DOI: 10.1039/d4ra08406c.

A Simplified Method for Evaluating Chitin-Binding Activity Applied to YKL-40 (HC-gp39, CHI3L1) and Chitotriosidase.

Suzuki K, Suzuki H, Tanaka A, Tanaka M, Takase K, Takei H Molecules. 2025; 30(1.

PMID: 39795077 PMC: 11721955. DOI: 10.3390/molecules30010019.

Hyperactivation of human acidic chitinase (Chia) for potential medical use.

Okawa K, Kijima M, Ishii M, Maeda N, Nanako M, Yasumura Y J Biol Chem. 2024; 301(1):108100.

PMID: 39706263 PMC: 11773036. DOI: 10.1016/j.jbc.2024.108100.

mRNA Vaccination: An Outlook on Innate Sensing and Adaptive Immune Responses.

Doost J, Fazel F, Boodhoo N, Sharif S Viruses. 2024; 16(9).

PMID: 39339880 PMC: 11437395. DOI: 10.3390/v16091404.

Valorization of Seafood Waste for Food Packaging Development.

Zhan Z, Feng Y, Zhao J, Qiao M, Jin Q Foods. 2024; 13(13).

PMID: 38998628 PMC: 11241680. DOI: 10.3390/foods13132122.

References

Jayakumar R, Prabaharan M, Nair S, Tamura H . Novel chitin and chitosan nanofibers in biomedical applications. Biotechnol Adv. 2009; 28(1):142-50. DOI: 10.1016/j.biotechadv.2009.11.001. View

Nakagawa T, Kaku H, Shimoda Y, Sugiyama A, Shimamura M, Takanashi K . From defense to symbiosis: limited alterations in the kinase domain of LysM receptor-like kinases are crucial for evolution of legume-Rhizobium symbiosis. Plant J. 2011; 65(2):169-80. DOI: 10.1111/j.1365-313X.2010.04411.x. View

Koller B, Muller-Wiefel A, Rupec R, Korting H, Ruzicka T . Chitin modulates innate immune responses of keratinocytes. PLoS One. 2011; 6(2):e16594. PMC: 3044707. DOI: 10.1371/journal.pone.0016594. View

Fujikawa T, Sakaguchi A, Nishizawa Y, Kouzai Y, Minami E, Yano S . Surface α-1,3-glucan facilitates fungal stealth infection by interfering with innate immunity in plants. PLoS Pathog. 2012; 8(8):e1002882. PMC: 3426526. DOI: 10.1371/journal.ppat.1002882. View

Vandenborre G, Smagghe G, Van Damme E . Plant lectins as defense proteins against phytophagous insects. Phytochemistry. 2011; 72(13):1538-50. DOI: 10.1016/j.phytochem.2011.02.024. View

Merzendorfer H . The cellular basis of chitin synthesis in fungi and insects: common principles and differences. Eur J Cell Biol. 2011; 90(9):759-69. DOI: 10.1016/j.ejcb.2011.04.014. View

Bueter C, Lee C, Rathinam V, Healy G, Taron C, Specht C . Chitosan but not chitin activates the inflammasome by a mechanism dependent upon phagocytosis. J Biol Chem. 2011; 286(41):35447-35455. PMC: 3195641. DOI: 10.1074/jbc.M111.274936. View

Bowman K, Leong K . Chitosan nanoparticles for oral drug and gene delivery. Int J Nanomedicine. 2007; 1(2):117-28. PMC: 2426784. DOI: 10.2147/nano.2006.1.2.117. View

Mora-Montes H, Netea M, Ferwerda G, Lenardon M, Brown G, Mistry A . Recognition and blocking of innate immunity cells by Candida albicans chitin. Infect Immun. 2011; 79(5):1961-70. PMC: 3088140. DOI: 10.1128/IAI.01282-10. View

10.

Reese T, Liang H, Tager A, Luster A, van Rooijen N, Voehringer D . Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature. 2007; 447(7140):92-6. PMC: 2527589. DOI: 10.1038/nature05746. View

11.

Seetharaman J, Kanigsberg A, Slaaby R, Leffler H, Barondes S, Rini J . X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution. J Biol Chem. 1998; 273(21):13047-52. DOI: 10.1074/jbc.273.21.13047. View

12.

Lee C, Da Silva C, Dela Cruz C, Ahangari F, Ma B, Kang M . Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury. Annu Rev Physiol. 2010; 73:479-501. PMC: 3864643. DOI: 10.1146/annurev-physiol-012110-142250. View

13.

Da Silva C, Chalouni C, Williams A, Hartl D, Lee C, Elias J . Chitin is a size-dependent regulator of macrophage TNF and IL-10 production. J Immunol. 2009; 182(6):3573-82. DOI: 10.4049/jimmunol.0802113. View

14.

Shibata Y, Foster L, Bradfield J, Myrvik Q . Oral administration of chitin down-regulates serum IgE levels and lung eosinophilia in the allergic mouse. J Immunol. 2000; 164(3):1314-21. DOI: 10.4049/jimmunol.164.3.1314. View

15.

Cash H, Whitham C, Behrendt C, Hooper L . Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science. 2006; 313(5790):1126-30. PMC: 2716667. DOI: 10.1126/science.1127119. View

16.

Kaku H, Nishizawa Y, Ishii-Minami N, Akimoto-Tomiyama C, Dohmae N, Takio K . Plant cells recognize chitin fragments for defense signaling through a plasma membrane receptor. Proc Natl Acad Sci U S A. 2006; 103(29):11086-91. PMC: 1636686. DOI: 10.1073/pnas.0508882103. View

17.

Dasgupta P, Keegan A . Contribution of alternatively activated macrophages to allergic lung inflammation: a tale of mice and men. J Innate Immun. 2012; 4(5-6):478-88. PMC: 6741623. DOI: 10.1159/000336025. View

18.

Semenuk T, Krist P, Pavlicek J, Bezouska K, Kuzma M, Novak P . Synthesis of chitooligomer-based glycoconjugates and their binding to the rat natural killer cell activation receptor NKR-P1. Glycoconj J. 2002; 18(10):817-26. DOI: 10.1023/a:1021111703443. View

19.

Schlosser A, Thomsen T, Moeller J, Nielsen O, Tornoe I, Mollenhauer J . Characterization of FIBCD1 as an acetyl group-binding receptor that binds chitin. J Immunol. 2009; 183(6):3800-9. DOI: 10.4049/jimmunol.0901526. View

20.

Kauss H, Jeblick W, Domard A . The degrees of polymerization and N-acetylation of chitosan determine its ability to elicit callose formation in suspension cells and protoplasts of Catharanthus roseus. Planta. 2013; 178(3):385-92. DOI: 10.1007/BF00391866. View