Diagnostic Difficulties in Fine Needle Aspiration of Benign Salivary Glandular Lesions

Overview

Journal Korean J Pathol

Specialty Pathology

Date 2013 Jan 17

PMID 23323108

Citations 7

Authors

Hye Jung Jo

Hyo Jung Ahn

Soojin Jung

Hye-Kyoung Yoon

Affiliations

Soon will be listed here.

Abstract

Background: The diagnostic accuracy of fine needle aspiration cytology (FNAC) of salivary lesions is relatively high, but cytologic interpretation might be confusing if the sample is lacking typical cytologic features.

Methods: There were 77 cases of benign salivary lesions, consisting of pleomorphic adenoma (PA) in 61 cases, Warthin's tumor (WT) in 12 cases, and other benign lesions in 4 cases. The causes of the discrepancies between the FNAC and the histologic diagnoses were evaluated.

Results: Major discrepancies were noted in 4 of the 61 PA cases, and in 1 of 12 WT cases. The causes of the major discrepancies were a mislabeled site in 1 PA and 1 WT case, and an interpretation error in 3 PA cases. Minor discrepancies were more common in the WT cases (7 of 12 cases) than in the PA cases (11 of 61 cases). The causes of the minor discrepancies were a mislabeled site in 1 PA and 1 WT case, an inadequate sample in 7 PA and 2 WT cases, a lack of typical cytomorphology in 2 PA and 2 WT cases, and an interpretation error in 1 PA and 2 WT cases.

Conclusions: To increase the diagnostic accuracy in the benign salivary lesions, recognition of both characteristic and less typical cytomorphology is needed.

Citing Articles

Different MRI-based radiomics models for differentiating misdiagnosed or ambiguous pleomorphic adenoma and Warthin tumor of the parotid gland: a multicenter study.

Yang J, Bi Q, Jin Y, Yang Y, Du J, Zhang H Front Oncol. 2024; 14:1392343.

PMID: 38939335 PMC: 11208325. DOI: 10.3389/fonc.2024.1392343.

Clinical decision making when cytology indicates a Warthin tumor.

Sirvio M, Aro K, Naukkarinen M, Makitie A, Tarkkanen J, Kelppe J Sci Rep. 2024; 14(1):8832.

PMID: 38632256 PMC: 11023945. DOI: 10.1038/s41598-024-58892-0.

Diagnostic Accuracy of Fine Needle Aspiration Cytology (FNAC) in Salivary Gland Lesions with Histopathological Examination (HPE) Correlation in a Tertiary Care Centre in Southern India.

Kasinathan B, Manohar B, Ganapathy H Indian J Otolaryngol Head Neck Surg. 2023; 75(2):871-879.

PMID: 37275112 PMC: 10234911. DOI: 10.1007/s12070-023-03550-6.

Diagnostic performance of qualitative and radiomics approach to parotid gland tumors: which is the added benefit of texture analysis?.

Vernuccio F, Arnone F, Cannella R, Verro B, Comelli A, Agnello F Br J Radiol. 2021; 94(1128):20210340.

PMID: 34591597 PMC: 8631014. DOI: 10.1259/bjr.20210340.

Salivary gland lesions: diagnostic reliability and challenges of fine needle aspiration cytology.

Chrabanska M, Kiczmer P, Drozdzowska B Int J Clin Exp Pathol. 2021; 14(1):54-62.

PMID: 33532023 PMC: 7847491.

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