Deconstructing the Brain's Moral Network: Dissociable Functionality Between the Temporoparietal Junction and Ventro-medial Prefrontal Cortex

Overview

Journal Soc Cogn Affect Neurosci

Specialties Neurology
Social Sciences

Date 2013 Jan 17

PMID 23322890

Citations 15

Authors

Oriel FeldmanHall

Dean Mobbs

Tim Dalgleish

Affiliations

Soon will be listed here.

Abstract

Research has illustrated that the brain regions implicated in moral cognition comprise a robust and broadly distributed network. However, understanding how these brain regions interact and give rise to the complex interplay of cognitive processes underpinning human moral cognition is still in its infancy. We used functional magnetic resonance imaging to examine patterns of activation for 'difficult' and 'easy' moral decisions relative to matched non-moral comparators. This revealed an activation pattern consistent with a relative functional double dissociation between the temporoparietal junction (TPJ) and ventro-medial prefrontal cortex (vmPFC). Difficult moral decisions activated bilateral TPJ and deactivated the vmPFC and OFC. In contrast, easy moral decisions revealed patterns of activation in the vmPFC and deactivation in bilateral TPJ and dorsolateral PFC. Together these results suggest that moral cognition is a dynamic process implemented by a distributed network that involves interacting, yet functionally dissociable networks.

Citing Articles

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References

Berthoz S, Armony J, Blair R, Dolan R . An fMRI study of intentional and unintentional (embarrassing) violations of social norms. Brain. 2002; 125(Pt 8):1696-708. DOI: 10.1093/brain/awf190. View

Castelli F, Frith C, Happe F, Frith U . Autism, Asperger syndrome and brain mechanisms for the attribution of mental states to animated shapes. Brain. 2002; 125(Pt 8):1839-49. DOI: 10.1093/brain/awf189. View

Gomot M, Bernard F, Davis M, Belmonte M, Ashwin C, Bullmore E . Change detection in children with autism: an auditory event-related fMRI study. Neuroimage. 2005; 29(2):475-84. DOI: 10.1016/j.neuroimage.2005.07.027. View

Moll J, Zahn R, de Oliveira-Souza R, Krueger F, Grafman J . Opinion: the neural basis of human moral cognition. Nat Rev Neurosci. 2005; 6(10):799-809. DOI: 10.1038/nrn1768. View

Young L, Saxe R . When ignorance is no excuse: Different roles for intent across moral domains. Cognition. 2011; 120(2):202-14. DOI: 10.1016/j.cognition.2011.04.005. View

Haidt J . The emotional dog and its rational tail: a social intuitionist approach to moral judgment. Psychol Rev. 2001; 108(4):814-34. DOI: 10.1037/0033-295x.108.4.814. View

Young L, Saxe R . An FMRI investigation of spontaneous mental state inference for moral judgment. J Cogn Neurosci. 2008; 21(7):1396-405. DOI: 10.1162/jocn.2009.21137. View

Young L, Cushman F, Hauser M, Saxe R . The neural basis of the interaction between theory of mind and moral judgment. Proc Natl Acad Sci U S A. 2007; 104(20):8235-40. PMC: 1895935. DOI: 10.1073/pnas.0701408104. View

Vrticka P, Andersson F, Grandjean D, Sander D, Vuilleumier P . Individual attachment style modulates human amygdala and striatum activation during social appraisal. PLoS One. 2008; 3(8):e2868. PMC: 2478709. DOI: 10.1371/journal.pone.0002868. View

10.

Moll J, Zahn R, de Oliveira-Souza R, Bramati I, Krueger F, Tura B . Impairment of prosocial sentiments is associated with frontopolar and septal damage in frontotemporal dementia. Neuroimage. 2010; 54(2):1735-42. PMC: 2997153. DOI: 10.1016/j.neuroimage.2010.08.026. View

11.

Moll J, de Oliveira-Souza R, Bramati I, Grafman J . Functional networks in emotional moral and nonmoral social judgments. Neuroimage. 2002; 16(3 Pt 1):696-703. DOI: 10.1006/nimg.2002.1118. View

12.

Greene J, Sommerville R, Nystrom L, Darley J, Cohen J . An fMRI investigation of emotional engagement in moral judgment. Science. 2001; 293(5537):2105-8. DOI: 10.1126/science.1062872. View

13.

Christensen J, Gomila A . Moral dilemmas in cognitive neuroscience of moral decision-making: a principled review. Neurosci Biobehav Rev. 2012; 36(4):1249-64. DOI: 10.1016/j.neubiorev.2012.02.008. View

14.

Shenhav A, Greene J . Moral judgments recruit domain-general valuation mechanisms to integrate representations of probability and magnitude. Neuron. 2010; 67(4):667-77. DOI: 10.1016/j.neuron.2010.07.020. View

15.

Heekeren H, Wartenburger I, Schmidt H, Schwintowski H, Villringer A . An fMRI study of simple ethical decision-making. Neuroreport. 2003; 14(9):1215-9. DOI: 10.1097/00001756-200307010-00005. View

16.

Valdesolo P, DeSteno D . Manipulations of emotional context shape moral judgment. Psychol Sci. 2006; 17(6):476-7. DOI: 10.1111/j.1467-9280.2006.01731.x. View

17.

Mesulam M . A cortical network for directed attention and unilateral neglect. Ann Neurol. 1981; 10(4):309-25. DOI: 10.1002/ana.410100402. View

18.

Raine A, Yang Y . Neural foundations to moral reasoning and antisocial behavior. Soc Cogn Affect Neurosci. 2008; 1(3):203-13. PMC: 2555414. DOI: 10.1093/scan/nsl033. View

19.

Tassy S, Oullier O, Duclos Y, Coulon O, Mancini J, Deruelle C . Disrupting the right prefrontal cortex alters moral judgement. Soc Cogn Affect Neurosci. 2011; 7(3):282-8. PMC: 3304479. DOI: 10.1093/scan/nsr008. View

20.

Decety J, Lamm C . The role of the right temporoparietal junction in social interaction: how low-level computational processes contribute to meta-cognition. Neuroscientist. 2007; 13(6):580-93. DOI: 10.1177/1073858407304654. View