Primary, Post-primary and Non-specific Immunoglobulin M Responses in HCV Infection

Overview

Journal Antivir Ther

Publisher Sage Publications

Specialties Infectious Diseases
Microbiology

Date 2013 Jan 17

PMID 23322600

Citations 5

Authors

Lynn B Dustin

Edgar D Charles

Affiliations

Soon will be listed here.

Abstract

Delayed and variable antibody responses to HCV make it difficult to diagnose acute HCV infection reliably. Immunoglobulin (Ig)M and IgG anti-HCV may be observed simultaneously as disease persists. IgM plays a key role in mixed cryoglobulinemia (MC), an immune complex disease strongly associated with persistent HCV infection. In MC, clonal or oligoclonal IgM rheumatoid factors facilitate the deposition of immune complexes in small blood vessels and tissue, leading to inflammation, complement activation and tissue damage. Clonally expanded IgM(+)κ(+) B-cells expressing rheumatoid factor-like IgM are abundant in many HCV patients with MC. The observation that identical or similar IgM antibodies are expressed in different patients' clonally expanded B-cells supports the hypothesis that MC is driven by antigen-specific B-cell activation, rather than polyclonal B-cell activation or HCV replication in B-cells. More study is required to identify the antigens that drive the development of MC.

Citing Articles

The Impact of Human Platelet Antigen Allele on Antiplatelet Antibodies and Cryoglobulins in Patients with Primary Immune Thrombocytopenia and Hepatitis C Virus-Associated Immune Thrombocytopenia.

Huang C, Chen Y, Chang J, Wu Y, Chen W, Wang Y Mediterr J Hematol Infect Dis. 2023; 15(1):e2023030.

PMID: 37180208 PMC: 10171212. DOI: 10.4084/MJHID.2023.030.

CD4 T Cell Differentiation in Chronic Viral Infections: The Tfh Perspective.

Vella L, Herati R, Wherry E Trends Mol Med. 2017; 23(12):1072-1087.

PMID: 29137933 PMC: 5886740. DOI: 10.1016/j.molmed.2017.10.001.

Innate and Adaptive Immune Responses in Chronic HCV Infection.

Dustin L Curr Drug Targets. 2015; 18(7):826-843.

PMID: 26302811 PMC: 5625838. DOI: 10.2174/1389450116666150825110532.

Activation-induced cytidine deaminase in B cells of hepatits C virus-related cryoglobulinaemic vasculitis.

Russi S, Dammacco F, Sansonno S, Pavone F, Sansonno D Clin Exp Immunol. 2015; 182(3):323-31.

PMID: 26219420 PMC: 4636894. DOI: 10.1111/cei.12690.

Immune control and failure in HCV infection--tipping the balance.

Dustin L, Cashman S, Laidlaw S J Leukoc Biol. 2014; 96(4):535-48.

PMID: 25015956 PMC: 4163633. DOI: 10.1189/jlb.4RI0214-126R.

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