Head Circumferences in Twins with and Without Autism Spectrum Disorders

Overview

Journal J Autism Dev Disord

Publisher Springer

Date 2013 Jan 17

PMID 23321801

Citations 8

Authors

Wendy Froehlich

Sue Cleveland

Andrea Torres

Jennifer Phillips

Brianne Cohen

Tiffany Torigoe

Janet Miller

Angie Fedele

Jack Collins

Karen Smith

Linda Lotspeich

Lisa A Croen

Sally Ozonoff

Clara Lajonchere

Judith K Grether

Joachim Hallmayer

Affiliations

Soon will be listed here.

Abstract

To determine the genetic relationship between head circumference (HC) and Autism Spectrum Disorders (ASDs). Twin pairs with at least one twin with an ASD were assessed. HCs in affected and unaffected individuals were compared, as were HC correlations in monozygotic and dizygotic pairs. 404 subjects, ages 4-18, were included. 20 % of males and 27 % of females with an ASD had macrocephaly. Unaffected co-twins showed similar rates (16 % of males and 22 % of females). Statistical analysis revealed no significant difference in HCs between affected and unaffected twins. Twins with ASDs and unaffected co-twins have similar HCs and increased rates of macrocephaly. Correlations demonstrated partial inheritance of HCs. Thus, macrocephaly may represent an endophenotype in ASDs.

Citing Articles

Behavioral and biological divergence in monozygotic twin pairs discordant for autism phenotypes: A systematic review.

Myers L, Pan P, Lundin Remnelius K, Neufeld J, Marschik P, Jonsson U JCPP Adv. 2023; 1(2):e12017.

PMID: 37431470 PMC: 10242874. DOI: 10.1111/jcv2.12017.

Brief Report: Macrocephaly Phenotype and Psychiatric Comorbidity in a Clinical Sample of Mexican Children and Adolescents with Autism Spectrum Disorders.

Albores-Gallo L, Fritsche-Garcia L, Miranda-Aguirre A, Avila-Acosta M J Autism Dev Disord. 2017; 47(9):2911-2917.

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Characterizing regression in Phelan McDermid Syndrome (22q13 deletion syndrome).

Reierson G, Bernstein J, Froehlich-Santino W, Urban A, Purmann C, Berquist S J Psychiatr Res. 2017; 91:139-144.

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Prenatal Neurogenesis in Autism Spectrum Disorders.

Kaushik G, Zarbalis K Front Chem. 2016; 4:12.

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Anthropometric assessment of a Middle Eastern group of autistic children.

Meguid N, Kandeel W, Wakeel K, El-Nofely A World J Pediatr. 2014; 10(4):318-23.

PMID: 25515805 DOI: 10.1007/s12519-014-0510-0.

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