Safety of Bronchial Arterial Embolization with N-butyl Cyanoacrylate in a Swine Model

Overview

Journal World J Radiol

Publisher Baishideng Publishing Group

Specialty Radiology

Date 2013 Jan 16

PMID 23320136

Citations 4

Authors

Takami Tanaka

Nobuyuki Kawai

Morio Sato

Akira Ikoma

Kouhei Nakata

Hiroki Sanda

Hiroki Minamiguchi

Motoki Nakai

Tetsuo Sonomura

Ichiro Mori

Affiliations

Soon will be listed here.

Abstract

Aim: To compare the efficacy and safety of bronchial artery embolization (BAE) with n-butyl cyanoacrylate (NBCA) and gelatin sponge particles (GSPs).

Methods: Six healthy female swine were divided into two groups to be treated with BAE using NBCA-lipiodol (NBCA-Lp) and using GSPs. The occlusive durability, the presence of embolic materials, the response of the vessel wall, and damage to the bronchial wall and pulmonary parenchyma were compared.

Results: No animals experienced any major complication. Two days later, no recanalization of the bronchial artery was observed in the NBCA-Lp group, while partial recanalization was seen in the GSP group. Embolic materials were not found in the pulmonary artery or pulmonary vein. NBCA-Lp was present as a bubble-like space in bronchial branch arteries of 127-1240 μm, and GSPs as reticular amorphous substance of 107-853 μm. These arteries were in the adventitia outside the bronchial cartilage but not in the fine vessels inside the bronchial cartilage. No damage to the bronchial wall and pulmonary parenchyma was found in either group. Red cell thrombus, stripping of endothelial cells, and infiltration of inflammatory cells was observed in vessels embolized with NBCA-Lp or GSP.

Conclusion: NBCA embolization is more potent than GSP with regard to bronchial artery occlusion, and both materials were present in bronchial branch arteries ≥ 100 μm diameter.

Citing Articles

Liver regeneration after portal vein embolization: comparison between absolute ethanol and -butyl-cyanoacrylate in an rat model.

Maruyama M, Takaki H, Yamada N, Hirata Y, Yamakado K, Kitagaki H Diagn Interv Radiol. 2023; 29(4):621-627.

PMID: 36994506 PMC: 10679635. DOI: 10.4274/dir.2022.211144.

Endovascular Use of Cyanoacrylate-Lipiodol Mixture for Peripheral Embolization: Properties, Techniques, Pitfalls, and Applications.

Comby P, Guillen K, Chevallier O, Lenfant M, Pellegrinelli J, Falvo N J Clin Med. 2021; 10(19).

PMID: 34640339 PMC: 8509239. DOI: 10.3390/jcm10194320.

In Vivo Experimental Endovascular Uses of Cyanoacrylate in Non-Modified Arteries: A Systematic Review.

Guillen K, Comby P, Chevallier O, Salsac A, Loffroy R Biomedicines. 2021; 9(9).

PMID: 34572467 PMC: 8472126. DOI: 10.3390/biomedicines9091282.

Effect of transcatheter arterial embolization with a mixture of n-butyl cyanoacrylate, lipiodol, and ethanol on the vascular wall: macroscopic and microscopic studies.

Tanaka F, Kawai N, Sato M, Minamiguchi H, Nakai M, Nakata K Jpn J Radiol. 2015; 33(7):404-9.

PMID: 25963344 DOI: 10.1007/s11604-015-0432-3.

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