Role of Complement in Multiorgan Failure

Overview

Journal Clin Dev Immunol

Specialty Allergy & Immunology

Date 2013 Jan 16

PMID 23320021

Citations 39

Authors

Daniel Rittirsch

Heinz Redl

Markus Huber-Lang

Affiliations

Soon will be listed here.

Abstract

Multiorgan failure (MOF) represents the leading cause of death in patients with sepsis and systemic inflammatory response syndrome (SIRS) following severe trauma. The underlying immune response is highly complex and involves activation of the complement system as a crucial entity of innate immunity. Uncontrolled activation of the complement system during sepsis and SIRS with in excessive generation of complement activation products contributes to an ensuing dysfunction of various organ systems. In the present review, mechanisms of the inflammatory response in the development of MOF in sepsis and SIRS with particular focus on the complement system are discussed.

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