A Case of Human Herpes Virus-8 Unrelated Primary Effusion Lymphoma-like Lymphoma Presented As Pleural Effusion

Overview

Journal Tuberc Respir Dis (Seoul)

Specialty Pulmonary Medicine

Date 2013 Jan 16

PMID 23319997

Citations 13

Authors

Kyung Ho Kim

Ji-Hyun Lee

Hye Cheol Jeong

Gun-Woo Kim

Sang Hee Song

So-Young Jung

Gwang Il Kim

Eun Kyung Kim

Affiliations

Soon will be listed here.

Abstract

Primary effusion lymphoma (PEL) is a rare type of lymphoma that arises in the body cavity without detectable masses. It is associated with human herpes virus-8 (HHV-8), Epstein-Barr virus (EBV), and human immunodeficiency virus (HIV). Recently, PEL unrelated to viral infection has been reported and it has been termed HHV-8 unrelated primary effusion lymphoma-like lymphoma (HHV-8 unrelated PEL-like lymphoma). Here, we report a case of HHV-8 unrelated PEL-like lymphoma in an 80-year-old woman. Chest X-ray and computed tomography revealed left-sided pleural effusion. Pleural effusion analysis and mediastinoscopic biopsy showed atypical cells that had originated from the B cells. The cells were positive for CD20 and bcl-2, but negative for CD3, CD5, CD21, CD30, CD138, epithelial membrane antigen, and HHV-8. Serological tests for HIV and EBV were negative. Considering the patient's age, further treatments were not performed. She has shown good prognosis without chemotherapy for more than 18 months.

Citing Articles

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