Matrix Metalloproteinases As Drug Targets in Preeclampsia

Overview

Journal Curr Drug Targets

Publisher Bentham Science Publishers

Specialty Pharmacology

Date 2013 Jan 16

PMID 23316964

Citations 35

Authors

Ana C T Palei

Joey P Granger

Jose E Tanus-Santos

Affiliations

Soon will be listed here.

Abstract

Preeclampsia is an important syndrome complicating pregnancy. While the pathogenesis of preeclampsia is not entirely known, poor placental perfusion leading to widespread maternal endothelial dysfunction is accepted as a major mechanism. It has been suggested that altered placental expression of matrix metalloproteinases (MMPs) may cause shallow cytotrophoblastic invasion and incomplete remodeling of the spiral arteries. MMPs are also thought to link placental ischemia to the cardiovascular alterations of preeclampsia. In fact, MMPs may promote vasoconstriction and surface receptors cleavage affecting the vasculature. Therefore, the overall goal of this review article is to provide an overview of the pathophisiology of preeclampsia, more specifically regarding the role of MMPs in the pathogenesis of preeclampsia and the potential of MMP inhibitors as therapeutic options.

Citing Articles

Antihypertensive therapy responsiveness and adverse outcomes in preeclampsia: insights into molecular mechanisms underlying cardiovascular and renal complications.

Luizon M, Pereira D, Mamede I, Ceron C, Cavalli R, Palei A Front Pharmacol. 2023; 14:1281382.

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Circulatory Maternal Endothelin 1 and Matrix Metalloproteinase-9 Gene Expression in PREECLAMPSIA: A Study in Western Uttar Pradesh, India.

Rao R, Sharma P, Padhy M, Sharma R, Gupta R, Bhatacharjee J J Obstet Gynaecol India. 2023; 73(Suppl 1):97-102.

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Matrix metalloproteinase-3 in preeclamptic and normotensive pregnancies complicated by foetal growth restriction.

Laskowska M, Dymara-Konopka W, Szmit E, Ledwich-Kibicka D, Wrobel A Heliyon. 2023; 9(7):e18105.

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The Oncogenic Theory of Preeclampsia: Is Amniotic Mesenchymal Stem Cells-Derived PLAC1 Involved?.

Conese M, Napolitano O, Laselva O, Di Gioia S, Nappi L, Trabace L Int J Mol Sci. 2023; 24(4).

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Expression as A Maternal Cell Free Plasma Biomarker of Severe Preeclampsia: A Case-Control Study.

Seydabadi S, Nikukar H, Vahdani F, Ramezanali F, Shahhoseini M, Favaedi R Cell J. 2023; 25(1):45-50.

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