Cobalt-catalyzed Acceptorless Alcohol Dehydrogenation: Synthesis of Imines from Alcohols and Amines

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2013 Jan 15

PMID 23311959

Citations 10

Authors

Guoqi Zhang

Susan K Hanson

Affiliations

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Abstract

A cobalt catalyst has been developed for the acceptorless dehydrogenation of alcohols and applied to synthesize imines from alcohols and amines. Deuterium labeling studies suggest that the reaction proceeds by an initial reversible alcohol dehydrogenation step involving a cobalt hydride intermediate.

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