Women's Higher Health Risks in the Obesogenic Environment: a Gender Nutrition Approach to Metabolic Dimorphism with Predictive, Preventive, and Personalised Medicine

Overview

Journal EPMA J

Date 2013 Jan 15

PMID 23311512

Citations 20

Authors

Niva Shapira

Affiliations

Soon will be listed here.

Abstract

Women's evolution for nurturing and fat accumulation, which historically yielded health and longevity advantages against scarcity, may now be counteracted by increasing risks in the obesogenic environment, recently shown by narrowing gender health gap. Women's differential metabolism/disease risks, i.e. in fat accumulation/distribution, exemplified during puberty/adolescence, suggest gender dimorphism with obesity outcomes. Women's higher body fat percentage than men, even with equal body mass index, may be a better risk predictor. Differential metabolic responses to weight-reduction diets, with women's lower abdominal fat loss, better response to high-protein vs. high-carbohydrate diets, higher risks with sedentariness vs. exercise benefits, and tendency toward delayed manifestation of central obesity, metabolic syndrome, diabetes, cardiovascular disease, and certain cancers until menopause-but accelerated thereafter-suggest a need for differing metabolic and chronological perspectives for prevention/intervention. These perspectives, including women's differential responses to lifestyle changes, strongly support further research with a gender nutrition emphasis within predictive, preventive, and personalized medicine.

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References

Finkelstein E, Brown D, Wrage L, Allaire B, Hoerger T . Individual and aggregate years-of-life-lost associated with overweight and obesity. Obesity (Silver Spring). 2009; 18(2):333-9. DOI: 10.1038/oby.2009.253. View

Latino-Martel P, Arwidson P, Ancellin R, Druesne-Pecollo N, Hercberg S, Le Quellec-Nathan M . Alcohol consumption and cancer risk: revisiting guidelines for sensible drinking. CMAJ. 2011; 183(16):1861-5. PMC: 3216427. DOI: 10.1503/cmaj.110363. View

Liu S, Manson J, Buring J, Stampfer M, Willett W, Ridker P . Relation between a diet with a high glycemic load and plasma concentrations of high-sensitivity C-reactive protein in middle-aged women. Am J Clin Nutr. 2002; 75(3):492-8. DOI: 10.1093/ajcn/75.3.492. View

Woolf K, Reese C, Mason M, Beaird L, Tudor-Locke C, Vaughan L . Physical activity is associated with risk factors for chronic disease across adult women's life cycle. J Am Diet Assoc. 2008; 108(6):948-59. DOI: 10.1016/j.jada.2008.03.015. View

Gennaro V, Ghirga G, Corradi L . In Italy, healthy life expectancy drop dramatically: from 2004 to 2008 there was a 10 years drop among newborn girls. Ital J Pediatr. 2012; 38:19. PMC: 3408327. DOI: 10.1186/1824-7288-38-19. View

De Lorenzo M, Baljinnyam E, Vatner D, Abarzua P, Vatner S, Rabson A . Caloric restriction reduces growth of mammary tumors and metastases. Carcinogenesis. 2011; 32(9):1381-7. PMC: 3165123. DOI: 10.1093/carcin/bgr107. View

Medrikova D, Jilkova Z, Bardova K, Janovska P, Rossmeisl M, Kopecky J . Sex differences during the course of diet-induced obesity in mice: adipose tissue expandability and glycemic control. Int J Obes (Lond). 2011; 36(2):262-72. DOI: 10.1038/ijo.2011.87. View

Yong V, Saito Y, Chan A . Gender differences in health and health expectancies of older adults in Singapore: an examination of diseases, impairments, and functional disabilities. J Cross Cult Gerontol. 2011; 26(2):189-203. DOI: 10.1007/s10823-011-9143-0. View

De Lorenzo A, Bianchi A, Maroni P, Iannarelli A, Di Daniele N, Iacopino L . Adiposity rather than BMI determines metabolic risk. Int J Cardiol. 2011; 166(1):111-7. DOI: 10.1016/j.ijcard.2011.10.006. View

10.

Mozaffarian D, Rimm E, Herrington D . Dietary fats, carbohydrate, and progression of coronary atherosclerosis in postmenopausal women. Am J Clin Nutr. 2004; 80(5):1175-84. PMC: 1270002. DOI: 10.1093/ajcn/80.5.1175. View

11.

Flegal K, Carroll M, Ogden C, Curtin L . Prevalence and trends in obesity among US adults, 1999-2008. JAMA. 2010; 303(3):235-41. DOI: 10.1001/jama.2009.2014. View

12.

Shapira N . Women's higher risk with N-6 PUFA vs. men's relative advantage: an "N-6 gender nutrition paradox" hypothesis. Isr Med Assoc J. 2012; 14(7):435-41. View

13.

Trovato F, Lalu N . Narrowing sex differentials in life expectancy in the industrialized world: early 1970's to early 1990's. Soc Biol. 1996; 43(1-2):20-37. DOI: 10.1080/19485565.1996.9988911. View

14.

Shai I, Wainstein J, Harman-Boehm I, Raz I, Fraser D, Rudich A . Glycemic effects of moderate alcohol intake among patients with type 2 diabetes: a multicenter, randomized, clinical intervention trial. Diabetes Care. 2007; 30(12):3011-6. DOI: 10.2337/dc07-1103. View

15.

Davidsen L, Vistisen B, Astrup A . Impact of the menstrual cycle on determinants of energy balance: a putative role in weight loss attempts. Int J Obes (Lond). 2007; 31(12):1777-85. DOI: 10.1038/sj.ijo.0803699. View

16.

McCartney G, Mahmood L, Leyland A, Batty G, Hunt K . Contribution of smoking-related and alcohol-related deaths to the gender gap in mortality: evidence from 30 European countries. Tob Control. 2011; 20(2):166-8. PMC: 3045524. DOI: 10.1136/tc.2010.037929. View

17.

Sies H, Stahl W, Sevanian A . Nutritional, dietary and postprandial oxidative stress. J Nutr. 2005; 135(5):969-72. DOI: 10.1093/jn/135.5.969. View

18.

Katsuki A, Sumida Y, Urakawa H, Gabazza E, Murashima S, Maruyama N . Increased visceral fat and serum levels of triglyceride are associated with insulin resistance in Japanese metabolically obese, normal weight subjects with normal glucose tolerance. Diabetes Care. 2003; 26(8):2341-4. DOI: 10.2337/diacare.26.8.2341. View

19.

Guo S, Zeller C, Chumlea W, Siervogel R . Aging, body composition, and lifestyle: the Fels Longitudinal Study. Am J Clin Nutr. 1999; 70(3):405-11. DOI: 10.1093/ajcn/70.3.405. View

20.

Yates T, Khunti K, Wilmot E, Brady E, Webb D, Srinivasan B . Self-reported sitting time and markers of inflammation, insulin resistance, and adiposity. Am J Prev Med. 2011; 42(1):1-7. DOI: 10.1016/j.amepre.2011.09.022. View