» Articles » PMID: 23304556

The Role of Radiotherapy and Chemotherapy in the Treatment of Primary Adult High Grade Gliomas: Assessment of Patients for These Treatment Approaches and the Common Immediate Side Effects

Overview
Journal ISRN Oncol
Specialty Oncology
Date 2013 Jan 11
PMID 23304556
Citations 6
Authors
Affiliations
Soon will be listed here.
Abstract

Gliomas are the commonest primary brain tumours in adults. They are usually classified and graded according to the criteria by the World Health Organisation. High-grade gliomas are the most malignant primary brain tumours. Conventional therapies include surgery, radiotherapy, and chemotherapy. The tumours often demonstrate high levels of resistance to these conventional therapies, and in spite of treatment advances the prognosis remains poor.

Citing Articles

Therapeutic effect of natural polyphenols against glioblastoma.

Beylerli O, Beilerli A, Shumadalova A, Wang X, Yang M, Sun H Front Cell Dev Biol. 2022; 10:1036809.

PMID: 36268515 PMC: 9577362. DOI: 10.3389/fcell.2022.1036809.


Hypofractionated radiation therapy with temozolomide versus standard chemoradiation in patients with glioblastoma multiforme (GBM): A prospective, single institution experience.

Rayan A, Abdel-Kareem S, Hasan H, Zahran A, Gamal D Rep Pract Oncol Radiother. 2020; 25(6):890-898.

PMID: 32982596 PMC: 7498706. DOI: 10.1016/j.rpor.2020.08.010.


Anesthetic effects of isoflurane and the molecular mechanism underlying isoflurane‑inhibited aggressiveness of hepatic carcinoma.

Hu J, Hu J, Jiao H, Li Q Mol Med Rep. 2018; 18(1):184-192.

PMID: 29749446 PMC: 6059668. DOI: 10.3892/mmr.2018.8945.


Effects of AQP5 gene silencing on proliferation, migration and apoptosis of human glioma cells through regulating EGFR/ERK/ p38 MAPK signaling pathway.

Yang J, Zhang J, Chen W, Wang G, Mao Q, Li S Oncotarget. 2017; 8(24):38444-38455.

PMID: 28404978 PMC: 5503544. DOI: 10.18632/oncotarget.16461.


Rhodomycin A, a novel Src-targeted compound, can suppress lung cancer cell progression via modulating Src-related pathways.

Lai Y, Chen M, Lin S, Lin S, Wong Y, Yu S Oncotarget. 2015; 6(28):26252-65.

PMID: 26312766 PMC: 4694899. DOI: 10.18632/oncotarget.4761.


References
1.
Hochberg F, Parker L, Takvorian T, Canellos G, Zervas N . High-dose BCNU with autologous bone marrow rescue for recurrent glioblastoma multiforme. J Neurosurg. 1981; 54(4):455-60. DOI: 10.3171/jns.1981.54.4.0455. View

2.
Levin V, Silver P, Hannigan J, Wara W, Gutin P, Davis R . Superiority of post-radiotherapy adjuvant chemotherapy with CCNU, procarbazine, and vincristine (PCV) over BCNU for anaplastic gliomas: NCOG 6G61 final report. Int J Radiat Oncol Biol Phys. 1990; 18(2):321-4. DOI: 10.1016/0360-3016(90)90096-3. View

3.
Bradac G, Soffietti R, Riva A, Stura G, Sales S, Schiffer D . Selective intra-arterial chemotherapy with BCNU in recurrent malignant gliomas. Neuroradiology. 1992; 34(1):73-6. DOI: 10.1007/BF00588438. View

4.
Laigle-Donadey F, Sanson M . [Pattern of care of high-grade gliomas]. Rev Prat. 2007; 56(16):1779-86. View

5.
Kita M, Okawa T, Tanaka M, Ikeda M . [Radiotherapy of malignant glioma--prospective randomized clinical study of whole brain vs local irradiation]. Gan No Rinsho. 1989; 35(11):1289-94. View