Symptoms, but Not a Biomarker Response to Inhaled Corticosteroids, Predict Asthma in Preschool Children with Recurrent Wheeze

Overview

Journal Mediators Inflamm

Publisher Wiley

Specialties Biochemistry
Pathology

Date 2013 Jan 11

PMID 23304059

Citations 5

Authors

E M M Klaassen

K D G van de Kant

Q Jobsis

S T P Hovig

C P van Schayck

G T Rijkers

E Dompeling

Affiliations

Soon will be listed here.

Abstract

Background: A reliable asthma diagnosis is challenging in preschool wheezing children. As inhaled corticosteroids (ICS) are more effective in asthmatics than in children with transient wheeze, an ICS response might be helpful in early asthma diagnosis.

Methods: 175 children (aged two-four years) with recurrent wheeze received 200 μg Beclomethasone extra-fine daily for eight weeks. Changes in Exhaled Breath Condensate (EBC) biomarkers (pH, interleukin (IL)-1α, IL-2, IL-4, IL-5, IL-10, IFN-γ, sICAM, and CCL-11), Fractional exhaled Nitric Oxide (FeNO), airway resistance, and symptoms were assessed. At six years of age a child was diagnosed as transient wheezer or asthmatic. Adjusted logistic regression analysis was performed with multiple testing correction.

Results: 106 transient wheezers and 64 asthmatics were analysed at six years of age. Neither changes in EBC biomarkers, nor FeNO, airway resistance, or symptoms during ICS trial at preschool age were related to asthma diagnosis at six years of age. However, asthmatics had more airway symptoms before the start of the ICS trial than transient wheezers (P < 0.01).

Discussion: Although symptom score in preschool wheezing children at baseline was associated with asthma at six years of age, EBC biomarkers, airway resistance, or symptom response to ICS at preschool age could not predict asthma diagnosis at six years of age.

Citing Articles

2020 Focused Updates to the Asthma Management Guidelines: A Report from the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group.

Cloutier M, Baptist A, Blake K, Brooks E, Bryant-Stephens T, DiMango E J Allergy Clin Immunol. 2020; 146(6):1217-1270.

PMID: 33280709 PMC: 7924476. DOI: 10.1016/j.jaci.2020.10.003.

The Role of FeNO in Predicting Asthma.

Pijnenburg M Front Pediatr. 2019; 7:41.

PMID: 30847334 PMC: 6393362. DOI: 10.3389/fped.2019.00041.

Biomarkers for Recurrent Wheezing and Asthma in Preschool Children.

Lee Y, Fujisawa T, Kim C Allergy Asthma Immunol Res. 2018; 11(1):16-28.

PMID: 30479074 PMC: 6267183. DOI: 10.4168/aair.2019.11.1.16.

An ADAM33 polymorphism associates with progression of preschool wheeze into childhood asthma: a prospective case-control study with replication in a birth cohort study.

Klaassen E, Penders J, Jobsis Q, van de Kant K, Thijs C, Mommers M PLoS One. 2015; 10(3):e0119349.

PMID: 25768087 PMC: 4358930. DOI: 10.1371/journal.pone.0119349.

Role of biomarkers in understanding and treating children with asthma: towards personalized care.

Lang J, Blake K Pharmgenomics Pers Med. 2013; 6:73-84.

PMID: 24019751 PMC: 3760446. DOI: 10.2147/PGPM.S30626.

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