Erythropoietin and Autoimmune Neuroinflammation: Lessons from Experimental Autoimmune Encephalomyelitis and Experimental Autoimmune Neuritis

Overview

Journal Anat Cell Biol

Specialty Anatomy & Histology

Date 2013 Jan 10

PMID 23301189

Citations 7

Authors

Taekyun Shin

Meejung Ahn

Changjong Moon

Seungjoon Kim

Affiliations

Soon will be listed here.

Abstract

Erythropoietin (EPO) is known to have numerous biological functions. While its primary function is during haematopoiesis, recent studies have shown that EPO plays important role in cytoprotection, immunomodulation, and antiapoptosis. These secondary functions of EPO are integral to tissue protection following hypoxic injury, ischemia-reperfusion injury, and spinal cord injury in the central nervous system. This review focuses on experimental evidence documenting the neuroprotective effects of EPO in organ-specific autoimmune nervous system disorders such as experimental autoimmune encephalomyelitis (EAE) and experimental autoimmune neuritis (EAN). In addition, the immunomodulatory role of EPO in the pathogenesis of EAE and EAN animal models of human multiple sclerosis and Guillain-Barré syndrome, respectively, will be discussed.

Citing Articles

Relationship between Hypoxic and Immune Pathways Activation in the Progression of Neuroinflammation: Role of HIF-1α and Th17 Cells.

Arias C, Sepulveda P, Castillo R, Salazar L Int J Mol Sci. 2023; 24(4).

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Expanding the Potential Therapeutic Options for Remote Ischemic Preconditioning: Use in Multiple Sclerosis.

Camara-Lemarroy C, Metz L, Smith E, Dunn J, Yong V Front Neurol. 2018; 9:475.

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Epobis is a Nonerythropoietic and Neuroprotective Agonist of the Erythropoietin Receptor with Anti-Inflammatory and Memory Enhancing Effects.

Dmytriyeva O, Pankratova S, Korshunova I, Walmod P Mediators Inflamm. 2016; 2016:1346390.

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Effects of erythropoietin preconditioning on rat cerebral ischemia-reperfusion injury and the GLT-1/GLAST pathway.

Yu D, Fan Y, Sun X, Yao L, Chai W Exp Ther Med. 2016; 11(2):513-518.

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A double-blind, placebo-controlled trial of adding erythropoietin to intravenous methylprednisolone for the treatment of unilateral acute optic neuritis of unknown or demyelinative origin.

Shayegannejad V, Shahzamani S, Dehghani A, Dast Borhan Z, Rahimi M, Mirmohammadsadeghi A Graefes Arch Clin Exp Ophthalmol. 2015; 253(5):797-801.

PMID: 25605544 DOI: 10.1007/s00417-014-2925-7.

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