» Articles » PMID: 23300358

Ubiquitin Pathway and Ovarian Cancer

Overview
Journal Curr Oncol
Publisher MDPI
Specialty Oncology
Date 2013 Jan 10
PMID 23300358
Citations 6
Authors
Affiliations
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Abstract

The ubiquitin-proteasome pathway is a common cellular process in eukaryotic tissue. Ubiquitin binds to proteins and tags them for destruction; this tagging directs proteins to the proteosome in the cell that degrades and recycles unneeded proteins. The ubiquitin-proteasome pathway plays an important role in the regulation of cellular proteins with respect to cell cycle control, transcription, apoptosis, cell adhesion, angiogenesis, and tumour growth. This review article discusses the various ways that the ubiquitin pathway is involved in ovarian cancer, such as modulating the ovarian-cancer-related gene BRCA1 and tumour suppressor p53, and interfering with the erk pathway, the cyclin-dependent cell cycle regulation process, and ERBB2 gene expression.

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References
1.
Bazzaro M, Lin Z, Santillan A, Lee M, Wang M, Chan K . Ubiquitin proteasome system stress underlies synergistic killing of ovarian cancer cells by bortezomib and a novel HDAC6 inhibitor. Clin Cancer Res. 2008; 14(22):7340-7. PMC: 2744414. DOI: 10.1158/1078-0432.CCR-08-0642. View

2.
Chan D, Liu V, Tsao G, Yao K, Furukawa T, Chan K . Loss of MKP3 mediated by oxidative stress enhances tumorigenicity and chemoresistance of ovarian cancer cells. Carcinogenesis. 2008; 29(9):1742-50. DOI: 10.1093/carcin/bgn167. View

3.
Brandt Y, Mitchell T, Wu Y, Hartley R . Developmental downregulation of Xenopus cyclin E is phosphorylation and nuclear import dependent and is mediated by ubiquitination. Dev Biol. 2011; 355(1):65-76. PMC: 3104060. DOI: 10.1016/j.ydbio.2011.04.014. View

4.
Al-Shami A, Jhaver K, Vogel P, Wilkins C, Humphries J, Davis J . Regulators of the proteasome pathway, Uch37 and Rpn13, play distinct roles in mouse development. PLoS One. 2010; 5(10):e13654. PMC: 2965108. DOI: 10.1371/journal.pone.0013654. View

5.
Ohta T, Fukuda M . Ubiquitin and breast cancer. Oncogene. 2004; 23(11):2079-88. DOI: 10.1038/sj.onc.1207371. View